Pharmacokinetics and brain uptake study of novel AMPA receptor antagonist perampanel in SD rats using a validated UHPLC‐QTOF‐MS method
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.11.008
Abstract: Graphical abstract Figure. No caption available. HighlightsThe method shows high sensitivity, very good precision and accuracy with short run time.Simple protein precipitation as sample preparation approach with good recovery from plasma/brain homogenate.The method found to… read more here.
Keywords: method; brain; perampanel rats; uptake study ... See more keywords
Abstract P6-10-05: UPTAKE study - Uptake of preventive surgeries among Latinas with BRCA1/2 mutations
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs17-p6-10-05
Abstract: Introduction: Germline testing for BRCA1/2 genes provides an opportunity to reduce mortality and morbidity by adopting appropriate risk reduction and screening options, in particular with risk-reducing bilateral salpingo-oophorectomy (BSO).There is a paucity of data on… read more here.
Keywords: uptake prophylactic; brca1; study; brca1 mutations ... See more keywords
Cell Line and Augument Cellular Uptake Study of Statistically Optimized Sustained Release Capecitabine Loaded Eudragit S100/PLGA(poly(lacticco- glycolic acid)) Nanoparticles for Colon Targeting.
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DOI: 10.2174/1567201813666160817150621
Abstract: BACKGROUND Capecitabine, an anti cancer drug, has a very short drug elimination half-life (0.49 to 0.89 h). High doses and absence of targeting ability in the colon region may lead to more side effects to… read more here.
Keywords: eudragit s100; uptake study; drug; s100 plga ... See more keywords