Cholesterol uptake or trafficking, steroid biosynthesis, and gonadotropin responsiveness are defective in young poor responders.
Sign Up to like & getrecommendations! Published in 2022 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2022.01.024
Abstract: OBJECTIVE To investigate whether poor ovarian response in young patients undergoing in vitro fertilization simply involves lesser follicle growth due to diminished ovarian reserve or whether there are intrinsic perturbations in the ovary. DESIGN A translational… read more here.
Keywords: cholesterol uptake; follicle; poor responders; hormone ... See more keywords
Active Uptake and Trafficking of Nucleoside Triphosphates In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00153
Abstract: Modified nucleoside triphosphates (NTPs) are powerful probes and medicines, but their anionic character impedes membrane permeability. As such, invasive delivery techniques, transport carriers, or prodrug strategies are required for their in vivo use. Here, we… read more here.
Keywords: active uptake; nucleoside triphosphates; tamra datp; uptake trafficking ... See more keywords
Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages
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DOI: 10.1111/mmi.14900
Abstract: Aluminum salts have been successfully utilized as adjuvants to enhance the immunogenicity of vaccine antigens since the 1930s. However, the cellular mechanisms behind the immune adjuvanticity effect of these materials in antigen‐presenting cells are poorly… read more here.
Keywords: aluminum; pertussis toxin; uptake trafficking; genetically detoxified ... See more keywords
The Uptake, Trafficking, and Biodistribution of Bacteroides thetaiotaomicron Generated Outer Membrane Vesicles
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.00057
Abstract: Gram-negative bacteria ubiquitously produce and release nano-size, non-replicative outer membrane vesicles (OMVs). In the gastrointestinal (GI-) tract, OMVs generated by members of the intestinal microbiota are believed to contribute to maintaining the intestinal microbial ecosystem… read more here.
Keywords: bacteroides thetaiotaomicron; trafficking biodistribution; membrane vesicles; outer membrane ... See more keywords