Design, Synthesis and Biological Evaluation of Uracil Derivatives as Novel VEGFR-2 Inhibitors.
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DOI: 10.2174/1381612824666180130123430
Abstract: BACKGROUND Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. Type I inhibitors constitute the major ATP-competitive inhibitors and recognize mainly the active conformation of VEGFR-2. Meanwhile, type… read more here.
Keywords: design synthesis; inhibitory activities; structure based; uracil ... See more keywords