Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.
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DOI: 10.1016/j.ejmech.2017.02.047
Abstract: A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based molecular hybridization to discover compounds with improved anti-resistance profiles. Anti-HIV activity of the designed compounds was tested in MT-4 cell cultures. The most… read more here.
Keywords: uracil bearing; based molecular; molecular hybridization; dapys derivatives ... See more keywords