Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.10.010
Abstract: Dipeptidyl peptidase-IV (DPP-4) is a validated target for T2DM treatment. We previously reported a novel series of triazole-based uracil derivatives bearing aliphatic carboxylic acids with potent DPP-4 inhibitory activities in vitro, but these compounds showed… read more here.
Keywords: dpp; based uracil; compound; triazole based ... See more keywords
A new method for designing bis-uracil derivatives as highly efficient and transparent PVC thermal stabilizer with excellent migration resistance
Sign Up to like & getrecommendations! Published in 2021 at "Polymer Degradation and Stability"
DOI: 10.1016/j.polymdegradstab.2021.109504
Abstract: Abstract A bis-uracil derivative with a long aliphatic chain of 11 carbon atoms, USU-C, was synthesized by an optimized method. The migration rate test indicated that USU-C had better migration resistance compared to OSU. This… read more here.
Keywords: pvc; uracil derivatives; bis uracil; migration ... See more keywords
Uracil derivatives as HIV-1 capsid protein inhibitors: design, in silico, in vitro and cytotoxicity studies
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02450k
Abstract: A series of novel uracil derivatives such as bispyrimidine dione and tetrapyrimidine dione derivatives were designed based on the existing four-point pharmacophore model as effective HIV capsid protein inhibitors. The compounds were initially docked with… read more here.
Keywords: hiv capsid; capsid protein; uracil derivatives; protein inhibitors ... See more keywords
Design, Synthesis and Biological Evaluation of Uracil Derivatives as Novel VEGFR-2 Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612824666180130123430
Abstract: BACKGROUND Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. Type I inhibitors constitute the major ATP-competitive inhibitors and recognize mainly the active conformation of VEGFR-2. Meanwhile, type… read more here.
Keywords: design synthesis; inhibitory activities; structure based; uracil ... See more keywords
Uracil Derivatives for Halogen-Bonded Cocrystals
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910663
Abstract: Among non-covalent interactions, halogen bonding is emerging as a new powerful tool for supramolecular self-assembly. Here, along with a green and effective method, we report three new halogen-bonded cocrystals containing uracil derivatives and 1,2,4,5-tetrafluoro-3,6-diiodobenzene as… read more here.
Keywords: halogen bonded; bonded cocrystals; halogen; spectroscopy ... See more keywords
Antiviral Activity of N1,N3-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of Concern
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231710171
Abstract: Despite the widespread use of the COVID-19 vaccines, the search for effective antiviral drugs for the treatment of patients infected with SARS-CoV-2 is still relevant. Genetic variability leads to the continued circulation of new variants… read more here.
Keywords: cov variants; variants concern; sars cov; activity ... See more keywords
The Facile Strategy of Improving the Long-Term Stability of Highly Transparent Polyvinyl Chloride by Introducing Unsaturated Zn Oleate and Uracil Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15072672
Abstract: In order to improve the initial color and the long-term heat stability of super-transparent polyvinyl chloride (PVC), a series of composite heat stabilizers consisting of unsaturated Zn oleate and uracil derivatives have been designed in… read more here.
Keywords: long term; uracil derivatives; oleate; stability ... See more keywords
Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15020544
Abstract: Over the past decades, both 4′-modified nucleoside and carbocyclic nucleoside analogs have been under the spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity. Herein, we designed compounds combining these… read more here.
Keywords: monophosphate prodrugs; substituted carbocyclic; synthesis substituted; carbocyclic uracil ... See more keywords