Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes
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DOI: 10.1007/s10067-021-05676-w
Abstract: We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms by which soluble mediators obtained from activated… read more here.
Keywords: urate crystals; monosodium urate; inflammatory mediators; oxidative stress ... See more keywords
Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care
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DOI: 10.1038/s41584-021-00725-9
Abstract: Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions, including hypertension, myocardial infarction, stroke, obesity, hyperlipidaemia, type 2 diabetes mellitus and chronic… read more here.
Keywords: cmr; risk; cardiometabolic renal; care ... See more keywords
Urate Crystals; Beyond Joints
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DOI: 10.3389/fmed.2021.649505
Abstract: Gout is the most common inflammatory arthropathy caused by the deposition of monosodium urate (MSU) crystals. The burden of gout is substantial with increasing prevalence of gout globally. The prevalence of Gout in the United… read more here.
Keywords: extra articular; deposition; urate crystals; msu crystals ... See more keywords
Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation.
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DOI: 10.3892/br.2017.960
Abstract: Uric acid is a known danger associated molecular pattern molecule able to induce inflammation following internalization of its crystals by cells of the innate immune system. By activating antigen-presenting cells, urate boosts adaptive immunity as… read more here.
Keywords: cell proliferation; induce; proliferation; urate crystals ... See more keywords