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Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-021-05676-w
Abstract: We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms by which soluble mediators obtained from activated…
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Keywords:
urate crystals;
monosodium urate;
inflammatory mediators;
oxidative stress ... See more keywords
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Published in 2021 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-021-00725-9
Abstract: Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions, including hypertension, myocardial infarction, stroke, obesity, hyperlipidaemia, type 2 diabetes mellitus and chronic…
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Keywords:
cmr;
risk;
cardiometabolic renal;
care ... See more keywords
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Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.649505
Abstract: Gout is the most common inflammatory arthropathy caused by the deposition of monosodium urate (MSU) crystals. The burden of gout is substantial with increasing prevalence of gout globally. The prevalence of Gout in the United…
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Keywords:
extra articular;
deposition;
urate crystals;
msu crystals ... See more keywords
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Published in 2017 at "Biomedical reports"
DOI: 10.3892/br.2017.960
Abstract: Uric acid is a known danger associated molecular pattern molecule able to induce inflammation following internalization of its crystals by cells of the innate immune system. By activating antigen-presenting cells, urate boosts adaptive immunity as…
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Keywords:
cell proliferation;
induce;
proliferation;
urate crystals ... See more keywords