Development and molecular modeling studies of new thiadiazole piperazine urea derivatives as potential fatty acid amide hydrolase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200082
Abstract: A series of novel piperazine urea derivatives with thiadiazole moieties were designed, synthesized, and investigated for their inhibition potential against human fatty acid amide hydrolase (hFAAH). The urea derivatives possessing p‐chlorophenylthiadiazole and benzylpiperazine fragments (19–22)… read more here.
Keywords: amide hydrolase; acid; piperazine urea; acid amide ... See more keywords
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21958
Abstract: The recent emergence of drug‐resistant strains of Mycobacterium tuberculosis (Mtb) has complicated and significantly slowed efforts to eradicate and/or reduce the worldwide incidence of life‐threatening acute and chronic cases of tuberculosis. To overcome this setback,… read more here.
Keywords: thiophenylthiazole moiety; inha inhibitory; carrying thiophenylthiazole; inhibitory ... See more keywords
Design, synthesis, molecular docking and cytotoxic activity of novel urea derivatives of 2-amino-3-carbomethoxythiophene
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-020-01834-w
Abstract: Abstract An efficient feasible route for the one-pot synthesis of novel series of urea derivatives (2a–2j) from 2-amino-3-carbomethoxythiophene (1) via in situ isocyanate has been developed, and their corresponding anticancer activities were accomplished. The series… read more here.
Keywords: urea derivatives; molecular docking; derivatives amino; amino carbomethoxythiophene ... See more keywords
Multiple molecular targets mediated antioxidant activity, molecular docking, ADMET, QSAR and bioactivity studies of halo substituted urea derivatives of α-Methyl-l-DOPA.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103708
Abstract: A series of novel α-methyl-l-DOPA urea derivatives viz., 3-(3,4-dihydroxyphenyl)-2-methyl-2-(3-halo/trifluoromethyl substituted phenyl ureido)propanoic acids (6a-e) have been synthesized from the reaction of α-methyl-l-DOPA (3) with various aryl isocyanates (4a-e) by using triethylamine (5, TEA) as a… read more here.
Keywords: antioxidant activity; docking admet; urea derivatives; methyl dopa ... See more keywords
Manganese Catalyzed Hydrogenation of Carbamates and Urea Derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b05591
Abstract: We report the hydrogenation of carbamates and urea derivatives, two of the most challenging carbonyl compounds to be hydrogenated, catalyzed for the first time by a complex of an earth-abundant-metal. The hydrogenation reaction of these… read more here.
Keywords: hydrogenation; urea derivatives; hydrogenation carbamates; manganese catalyzed ... See more keywords
Synthesis of urea derivatives via reductive carbon dioxide fixation into contracted porphyrin analogues
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DOI: 10.1039/c7gc02798b
Abstract: Carbon dioxide from ammonium carbonate is trapped by the free base corroles with the help of two adjacent inner NH groups (N21 and N22) and forms the N21,N22-carbamide-corrole derivatives. There is an extensive literature on… read more here.
Keywords: carbon dioxide; urea derivatives; n21 n22; n22 carbamide ... See more keywords
Biochemical and microbiological evaluation of N-aryl urea derivatives against mycobacteria and mycobacterial hydrolases.
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DOI: 10.1039/c9md00122k
Abstract: A focused library of 24 N-aryl urea derivatives was prepared and evaluated against serine esterases of Mycobacterium tuberculosis (Mtb) Rv3802c and Mtb Ag85C. The members of the library were evaluated for both selectivity and mode… read more here.
Keywords: biochemical microbiological; aryl urea; urea derivatives; mtb ... See more keywords
Anion binding with biphenyl-bis-urea derivatives: solution and solid-state studies
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DOI: 10.1039/d0nj03670f
Abstract: In this work, we have synthesized and characterized bis-urea derivatives 1–3, featuring a biphenyl spacer, and studied their anion binding properties in DMSO solution and in the solid state. In solution, 1 : 1 complexes were observed… read more here.
Keywords: solid state; bis urea; urea derivatives; solution solid ... See more keywords
New thiourea and urea derivatives containing trifluoromethyl- and bis-triflouromethyl-4H-chromen-3-yl substituents
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Physics"
DOI: 10.1080/00268976.2018.1514132
Abstract: ABSTRACT Two new thiourea (1) and urea (2) derivatives, substituted with 2-trifluoromethyl-4H-chromen-3-yl moieties at defined positions, were obtained by convenient synthetic methodologies. The pure compounds were studied in solid state by vibrational spectroscopy (FT-IR and… read more here.
Keywords: urea derivatives; containing trifluoromethyl; derivatives containing; thiourea urea ... See more keywords
Solution and Solid State Studies of Urea Derivatives of DITIPIRAM Acting as Powerful Anion Receptors
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DOI: 10.3390/molecules26061788
Abstract: Herein, we present the synthesis and anion binding studies of a family of homologous molecular receptors 4–7 based on a DITIPIRAM (8-propyldithieno-[3,2-b:2′,3′-e]-pyridine-3,5-di-amine) platform decorated with various urea para-phenyl substituents (NO2, F, CF3, and Me). Solution,… read more here.
Keywords: solid state; anion; studies urea; urea derivatives ... See more keywords
Synthesis and characterization of some novel diaryl urea derivatives bearing quinoxalindione moiety
Sign Up to like & getrecommendations! Published in 2018 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.220971
Abstract: Diaryl urea derivatives have exhibited a broad spectrum of biochemical effects and pharmaceutical applications. Several diaryl urea derivatives such as sorafenib, regorafenib, linifanib, and tivozanib and lenvatinib are in clinical trial or clinical use. Therefore,… read more here.
Keywords: urea derivatives; quinoxalindione moiety; diaryl urea; synthesis characterization ... See more keywords