Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.
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DOI: 10.1021/acsmedchemlett.2c00079
Abstract: Formyl peptide receptor 2 (FPR2) agonists have shown efficacy in inflammatory-driven animal disease models and have the potential to treat a range of diseases. Many reported synthetic agonists contain a phenylurea, which appears to be… read more here.
Keywords: urea isosteres; heteroaryl urea; discovery heteroaryl; peptide receptor ... See more keywords