The urea transporter DUR3 is differentially regulated by abiotic and biotic stresses in coffee plants
Sign Up to like & getrecommendations! Published in 2021 at "Physiology and Molecular Biology of Plants"
DOI: 10.1007/s12298-021-00930-6
Abstract: The high costs of N fertilizers in the coffee production emphasizes the need to optimize fertilization practices and improve nitrogen use efficiency. Urea is widespread in nature, characterizing itself as a significant source of nitrogen… read more here.
Keywords: stresses coffee; abiotic biotic; coffee plants; biotic stresses ... See more keywords
Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.03.060
Abstract: Urea transporters (UTs) play an important role in the urine concentrating mechanism and are recognized as novel targets for developing small molecule inhibitors with salt-sparing diuretic activity. Thienoquinoline derivatives, a class of novel UT-B inhibitors… read more here.
Keywords: transporter inhibitors; discovery optimization; thienopyridine derivatives; urea transporter ... See more keywords
Molecular dynamics simulation of human urea transporter B
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Simulation"
DOI: 10.1080/08927022.2021.1941944
Abstract: ABSTRACT We applied a new large two membrane model of human urea transporter B (UT-B) with urea concentration gradient between intracellular and extracellular solution to explore the structure and dynamics of urea permeation. The first… read more here.
Keywords: urea permeation; molecular dynamics; simulation; human urea ... See more keywords
The urea transporter DUR3 contributes to rice production under nitrogen-deficient and field conditions.
Sign Up to like & getrecommendations! Published in 2018 at "Physiologia plantarum"
DOI: 10.1111/ppl.12872
Abstract: Nitrogen is one of the most important elements for plant growth, and urea is one of the most frequently used nitrogen fertilizers worldwide. Besides the exogenously-supplied urea to the soil, urea is endogenously synthesized during… read more here.
Keywords: production; dur3; field; transporter dur3 ... See more keywords
The knockout of urea transporter-B improves the hemorheological properties of erythrocyte.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical hemorheology and microcirculation"
DOI: 10.3233/ch-16174
Abstract: OBJECTIVE Urea transporter-B (UT-B), highly expressed in erythrocyte, confers specific permeability to urea, urea analogues and water. The purpose of this study was to determine the hemorheological properties of UT-B null erythrocyte using a series… read more here.
Keywords: properties erythrocyte; improves hemorheological; mice; hemorheological properties ... See more keywords
Substrate Recognition Properties from an Intermediate Structural State of the UreA Transporter
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416039
Abstract: Through a combination of comparative modeling, site-directed and classical random mutagenesis approaches, we previously identified critical residues for binding, recognition, and translocation of urea, and its inhibition by 2-thiourea and acetamide in the Aspergillus nidulans… read more here.
Keywords: recognition; w82 w84; urea transporter; state urea ... See more keywords