Endophytic fungus Paecilomyces formosus LHL10 produces sester-terpenoid YW3548 and cyclic peptide that inhibit urease and α-glucosidase enzyme activities
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Microbiology"
DOI: 10.1007/s00203-018-1562-7
Abstract: Endophytic fungi have been used to obtain novel bioactive secondary metabolites with potential applications in medical and agricultural sectors, which can also act as lead targets for pharmaceutical and medicinal potential. In the present study,… read more here.
Keywords: endophytic fungus; fungus paecilomyces; urease glucosidase; paecilomyces formosus ... See more keywords
Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06694
Abstract: In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (2a–2q) was designed and synthesized by employing a multistep strategy, and the newly synthesized compounds were screened for their urease and α-glucosidase inhibitory activities. The compounds… read more here.
Keywords: dual inhibitors; glucosidase; urease glucosidase; potent dual ... See more keywords