Articles with "uremic syndrome" as a keyword



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Novel homozygous CD46 variant with C‐isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome

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Published in 2022 at "European Journal of Immunology"

DOI: 10.1002/eji.202249838

Abstract: Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy that may lead to organ failure. Dysregulation of the complement system can cause aHUS, and various disease‐related variants in the complement regulatory protein CD46 are described.… read more here.

Keywords: atypical hemolytic; expression; uremic syndrome; cd46 ... See more keywords
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Blood urea nitrogen to serum creatinine ratio as a prognostic factor in diarrhea-associated hemolytic uremic syndrome: a validation study

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Published in 2017 at "European Journal of Pediatrics"

DOI: 10.1007/s00431-017-2999-4

Abstract: AbstractIdentifying those children with complicated forms of diarrhea-associated hemolytic uremic syndrome (D+HUS) on admission can optimize their management. Recently, the blood urea nitrogen to serum creatinine ratio (BCR) at admission has been proposed as a… read more here.

Keywords: uremic syndrome; admission; diarrhea associated; study ... See more keywords
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Outbreak of Shiga toxin-producing Escherichia-coli-associated hemolytic uremic syndrome in Istanbul in 2015: outcome and experience with eculizumab

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Published in 2018 at "Pediatric Nephrology"

DOI: 10.1007/s00467-018-4033-0

Abstract: BackgroundThis study aims to identify epidemiological and clinical characteristics of patients and report our experience with eculizumab treatment during an outbreak of hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) in Istanbul… read more here.

Keywords: uremic syndrome; toxin producing; hemolytic uremic; experience eculizumab ... See more keywords
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C3 levels and acute outcomes in Shiga toxin–related hemolytic uremic syndrome

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Published in 2019 at "Pediatric Nephrology"

DOI: 10.1007/s00467-019-04334-3

Abstract: Background The correlation between complement activation and severity of hemolytic uremic syndrome related to Shiga toxin–producing Escherichia coli (STEC-HUS) has been examined in few studies, with conflicting results. We investigated whether C3 levels on admission… read more here.

Keywords: uremic syndrome; acute outcomes; hemolytic uremic; shiga toxin ... See more keywords
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Rasburicase in hemolytic uremic syndrome related to Shiga toxin-producing Escherichia coli: a report of nine cases

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Published in 2020 at "Pediatric Nephrology"

DOI: 10.1007/s00467-020-04528-0

Abstract: Background Hyperuricemia might induce additional renal damage in children with hemolytic uremic syndrome related to Shiga toxin-producing Escherichia coli (STEC-HUS). A few case reports have shown rasburicase to be effective in decreasing serum uric acid… read more here.

Keywords: uremic syndrome; rasburicase; syndrome related; related shiga ... See more keywords
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Interleukin-33/ST2 signaling contributes to the severity of hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli

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Published in 2018 at "Clinical and Experimental Nephrology"

DOI: 10.1007/s10157-018-1675-y

Abstract: ObjectivesInterleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33’s role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also… read more here.

Keywords: serum sst2; uremic syndrome; induced enterohemorrhagic; serum ... See more keywords
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Clinical characteristics of children with hemolytic uremic syndrome in Hangzhou, China

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Published in 2017 at "World Journal of Pediatrics"

DOI: 10.1007/s12519-017-0021-x

Abstract: BackgroundHemolytic uremic syndrome (HUS) is a main cause of acute renal failure in children. This study aimed to analyze the clinical characteristics of HUS.MethodsA retrospective analysis was performed in 46 children with sporadic HUS.ResultsOf the… read more here.

Keywords: characteristics children; uremic syndrome; children hemolytic; hemolytic uremic ... See more keywords
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Atypical hemolytic uremic syndrome due to DGKE mutation and response to eculizumab: lessons for the clinical nephrologist

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Published in 2021 at "Journal of Nephrology"

DOI: 10.1007/s40620-020-00925-8

Abstract: An 18-month-old white boy presented with non-bloody diarrhea and pallor and one week of cough and nasal congestion. On examination, he was hypertensive (115/99) and tachycardic (140 bpm). Pertinent labs included normocytic hemolytic anemia with… read more here.

Keywords: atypical hemolytic; uremic syndrome; hemolytic uremic; eculizumab ... See more keywords
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Hemolytic Uremic Syndrome

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Published in 2020 at "Current Treatment Options in Pediatrics"

DOI: 10.1007/s40746-020-00216-1

Abstract: The emergence of specific treatment of atypical hemolytic uremic syndrome (aHUS) using eculizumab has allowed renal function recovery and safe kidney transplantation (KT). Early and precise recognition of complement-mediated (CM) atypical HUS (aHUS) is challenging… read more here.

Keywords: hus; uremic syndrome; treatment; hemolytic uremic ... See more keywords
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Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome

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Published in 2017 at "Chest"

DOI: 10.1016/j.chest.2017.03.055

Abstract: &NA; A typical hemolytic uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic microangiopathy (TMA), such as disseminated intravascular coagulation or sepsis. Similarity in clinical presentation may… read more here.

Keywords: uremic syndrome; patients ahus; hemolytic uremic; critically ill ... See more keywords
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Shigella sonnei and hemolytic uremic syndrome: A case report and literature review

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Published in 2017 at "IDCases"

DOI: 10.1016/j.idcr.2017.02.003

Abstract: Hemolytic uremic syndrome (HUS) is a well-described process that is known to cause severe renal dysfunction, thrombocytopenia, and anemia. HUS is typically associated with toxins (shiga-like and shigella toxin) found in strains of E. coli… read more here.

Keywords: uremic syndrome; case; hemolytic uremic; shigella ... See more keywords