Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4366
Abstract: Indoxyl sulphate (IS) is a uremic toxin accumulating in the plasma of chronic kidney disease (CKD) patients. IS accumulation induces side effects in the kidneys, bones and cardiovascular system. Most studies assessed IS effects on… read more here.
Keywords: human microvascular; uremic toxin; indoxyl sulphate; microvascular endothelial ... See more keywords
The Uremic Toxin P-Cresol Reduces Cell Surface Expression of Human Ether-A-Go Go-Related Gene (hERG) Channels via the Ubiquitin Ligase Nedd4-2
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2953
Abstract: 2695-Pos Board B302 The Uremic Toxin P-Cresol Reduces Cell Surface Expression of Human Ether-A-Go Go-Related Gene (hERG) Channels via the Ubiquitin Ligase Nedd4-2 Ellen G. Avery, Shawn Lamothe, Shetuan Zhang, Jun Guo, Wentao Li, Tonghua… read more here.
Keywords: toxin cresol; cresol; herg; herg channels ... See more keywords
Computational investigations of Bio-MOF membranes for uremic toxin separation
Sign Up to like & getrecommendations! Published in 2022 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2021.119852
Abstract: Abstract Developing new and efficient methods as an alternative to hemodialysis is important due to the challenges associated with poor efficiency of membranes and long dialysis sessions. Recently, metal organic frameworks (MOFs) have attracted interest… read more here.
Keywords: water; toxin separation; toxin; uremic toxin ... See more keywords
Molecular mechanisms of protein-bound uremic toxin-mediated cardiac, renal and vascular effects: underpinning intracellular targets for cardiorenal syndrome therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.03.002
Abstract: Cardiorenal syndrome (CRS) remains a global health burden with a lack of definitive and effective treatment. Protein-bound uremic toxin (PBUT) overload has been identified as a non-traditional risk factor for cardiac, renal and vascular dysfunction… read more here.
Keywords: protein bound; bound uremic; cardiac renal; renal vascular ... See more keywords
Urea, a true uremic toxin: the empire strikes back.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical science"
DOI: 10.1042/cs20160203
Abstract: Blood levels of urea rise with progressive decline in kidney function. Older studies examining acute urea infusion suggested that urea was well-tolerated at levels 8-10× above normal values. More recent in vitro and in vivo work argue… read more here.
Keywords: toxin empire; empire strikes; true uremic; uremic toxin ... See more keywords
Systematic Comparison of Uremic Toxin Removal Using Different Hemodialysis Modes: A Single-Center Crossover Prospective Observational Study
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020373
Abstract: Many hypotheses could explain the mortality decrease observed using hemodiafiltration, such as reduction of intradialytic hypotension and more efficient toxin removal. We led a systematic analysis of representative uremic toxin removal with hemodialysis (HD), online… read more here.
Keywords: toxin removal; removal; reduction ratio; reduction ... See more keywords
Uremia-Induced Gut Barrier Defect in 5/6 Nephrectomized Mice Is Worsened by Candida Administration through a Synergy of Uremic Toxin, Lipopolysaccharide, and (1➔3)-β-D-Glucan, but Is Attenuated by Lacticaseibacillus rhamnosus L34
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052511
Abstract: A chronic kidney disease (CKD) causes uremic toxin accumulation and gut dysbiosis, which further induces gut leakage and worsening CKD. Lipopolysaccharide (LPS) of Gram-negative bacteria and (1➔3)-β-D-glucan (BG) of fungi are the two most abundant… read more here.
Keywords: rhamnosus l34; toxin; mice; lacticaseibacillus rhamnosus ... See more keywords
Temperature Responsive Polymer Conjugate Prepared by “Grafting from” Proteins toward the Adsorption and Removal of Uremic Toxin
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DOI: 10.3390/molecules27031051
Abstract: In this study, temperature-responsive polymer-protein conjugate was synthesized using a “grafting from” concept by introducing a chain transfer agent (CTA) into bovine serum albumin (BSA). The BSA-CTA was used as a starting point for poly(N-isopropylacrylamide)… read more here.
Keywords: temperature responsive; responsive polymer; pnipaam; conjugate ... See more keywords
What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis
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DOI: 10.3390/toxins14030221
Abstract: The topic of uremic toxicity has received broad attention from the nephrological community over the past few decades. An aspect that is much less often considered is the possibility that the metabolic pathways that generate… read more here.
Keywords: metabolites uremic; toxin; tryptophan derived; derived metabolites ... See more keywords