Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2).
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DOI: 10.1021/acs.biochem.2c00451
Abstract: Pyrimidine nucleotide biosynthesis in humans is a promising chemotherapeutic target for infectious diseases caused by RNA viruses. Because mammalian cells derive pyrimidine ribonucleotides through a combination of de novo biosynthesis and salvage, combined inhibition of… read more here.
Keywords: inhibitors human; kinase uck2; cytidine kinase; uridine cytidine ... See more keywords
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
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DOI: 10.1042/bcj20210770
Abstract: Uridine-cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein with high sequence similarity to other uridine-cytidine kinases (UCKs). UCKs play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine… read more here.
Keywords: cytidine; uridine cytidine; tumor growth; kinase ... See more keywords