Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-Pα,α-Dithiophosphate Analogues.
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DOI: 10.1021/acs.jmedchem.7b01906
Abstract: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) hydrolyzes phosphodiester bonds of nucleotides such as ATP, resulting mainly in the formation of AMP and pyrophosphate. NPP1 activity plays a deleterious function in calcified aortic valve disease and calcium pyrophosphate deposition… read more here.
Keywords: ectonucleotide pyrophosphatase; npp1; inhibitors based; uridine dithiophosphate ... See more keywords