LRBA is essential for urinary concentration and body water homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202125119
Abstract: Significance Water transport via aquaporin-2 (AQP2) water channels is a critical determinant of urine volume. Antidiuretic hormone vasopressin activates renal protein kinase A (PKA) and then directly phosphorylates AQP2, which promotes AQP2 translocation from intracellular… read more here.
Keywords: urinary concentration; water; concentration body; body water ... See more keywords
Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin 2
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.182087
Abstract: Urinary concentration is an energy-dependent process that minimizes body water loss by increasing aquaporin 2 (AQP2) expression in collecting duct (CD) principal cells. To investigate the role of mitochondrial (mt) ATP production in renal water… read more here.
Keywords: urinary concentration; electron transport; concentration; aqp2 ... See more keywords