Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and Construction of a Nomogram
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70762
Abstract: Colorectal polyps (CRPs) are precursors to colorectal cancer (CRC), and early detection is crucial for prevention. Traditional diagnostic methods are invasive, prompting a need for noninvasive biomarkers. This study aimed to identify urinary metabolite biomarkers… read more here.
Keywords: metabolite; noninvasive urinary; colorectal polyps; metabolite screening ... See more keywords
Evaluation of a Chemiluminescent Enzyme Immunoassay for the Detection of Prostaglandin E‐Major Urinary Metabolite (PGE‐MUM)
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.25102
Abstract: We developed a fully automated quantitative immunoassay for the detection of prostaglandin E‐major urinary metabolite (PGE‐MUM). In this study, we evaluated the analytical performance of this assay. read more here.
Keywords: prostaglandin major; immunoassay detection; metabolite pge; major urinary ... See more keywords
LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8579-1_15
Abstract: A method was developed for the analysis of stimulant drugs, opiates, synthetic opiates, PCP, and benzodiazepines in wastewater samples using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS). A total of 33 compounds (stimulant-type drugs… read more here.
Keywords: metabolite; primary urinary; opiates pcp; opiates synthetic ... See more keywords
Expanding Urinary Metabolite Annotation through Integrated Mass Spectral Similarity Networking.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c02041
Abstract: The urine metabolome constitutes a rich source of functional information reflecting physiological states that are influenced by distinct conditions and biological stresses, such as responses to drug treatments or disease manifestations. Although global liquid chromatography-mass… read more here.
Keywords: annotation integrated; expanding urinary; similarity; annotation ... See more keywords
Identification of 4'-Demethyltangeretin as a Major Urinary Metabolite of Tangeretin in Mice and Its Anti-inflammatory Activities.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c06334
Abstract: The present study showed that oral administration of tangeretin (TAN) in mice resulted in the production of 4'-demethyltangeretin (4DT) as a major urinary metabolite. The anti-inflammatory efficacy of TAN and 4DT was determined in RAW… read more here.
Keywords: anti inflammatory; demethyltangeretin; major urinary; tangeretin ... See more keywords
Synthesis of a Human Urinary Metabolite of Prostaglandin D2.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03983
Abstract: A chemical synthesis of the major human metabolite of prostaglandin D2, tricyclic-PGDM, is described. The synthetic route starts from iodocyclopentenone 1 (available from cyclopentadiene in 6 steps) and requires 13 synthetic transformations. The synthetic route… read more here.
Keywords: metabolite prostaglandin; synthesis human; human urinary; metabolite ... See more keywords
Meta-analysis of urinary metabolite GWAS studies identifies novel genome-wide significant loci
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-07518-0
Abstract: Genome-wide association studies (GWAS) have substantially enhanced the understanding of genetic influences on phenotypic outcomes; however, realizing their full potential requires an aggregate analysis of numerous studies. Here we represent the first comprehensive meta-analysis of… read more here.
Keywords: meta; metabolite gwas; analysis; gwas ... See more keywords