Comparison of enteral and parenteral methods of urine alkalinization in patients receiving high-dose methotrexate
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155215610914
Abstract: Purpose Hyperhydration and urinary alkalinization is implemented with all high-dose (HD)-methotrexate infusions to promote excretion and prevent precipitation of methotrexate in the renal tubules. Our institution utilized enteral alkalinizing agents (sodium bicarbonate tablets and sodium… read more here.
Keywords: alkalinization; sodium bicarbonate; urine alkalinization; time ... See more keywords
Evaluation of methotrexate clearance with an enteral urine alkalinization protocol for patients receiving high-dose methotrexate
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DOI: 10.1177/1078155220908946
Abstract: Purpose High-dose methotrexate is a cytotoxic agent used to treat several malignancies. Urine alkalinization with sodium bicarbonate and hyperhydration are given with methotrexate to prevent drug precipitation in the kidneys. Due to a nationwide intravenous… read more here.
Keywords: methotrexate clearance; urine alkalinization; methotrexate; sodium bicarbonate ... See more keywords
Recommended oral sodium bicarbonate administration for urine alkalinization did not affect the concentration of mitomycin-C in non-muscle invasive bladder cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21755
Abstract: Objective Sodium bicarbonate has been reported to maximize the efficacy of intravesical instillation of mitomycin-C (IVI-MMC) therapy by urine alkalinization in non-muscle-invasive bladder cancer (NMIBC). This study aimed to analyze the changes in MMC concentration… read more here.
Keywords: concentration; sodium bicarbonate; urine alkalinization; mmc ... See more keywords