Comprehensive metabolic study of IOX4 in equine urine and plasma using liquid chromatography/electrospray ionization Q Exactive high-resolution mass spectrometer for the purpose of doping control.
Sign Up to like & getrecommendations! Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3172
Abstract: IOX4 is a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, which was developed for the treatment of anemia by exerting hematopoietic effects. The administration of HIF-PHD inhibitors such as IOX4 to horses is strictly prohibited by… read more here.
Keywords: plasma; urine plasma; metabolic study; comprehensive metabolic ... See more keywords
Identification of potential biomarkers in urine and plasma after consumption of tobacco product in horses.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3242
Abstract: The use of nicotine stimulants in horses is generally banned in horse racing and equestrian sports-accidental consumption of tobacco products is one of the possible causes of nicotine exposure in horses. The authors recently reported… read more here.
Keywords: potential biomarkers; tobacco product; tobacco; consumption tobacco ... See more keywords
Equine metabolism of the selective androgen receptor modulator YK-11 in urine and plasma following oral administration.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3425
Abstract: YK-11 is a steroidal selective androgen receptor modulator, a compound class prohibited in both equine racing and human sports because of their potentially performance enhancing properties. YK-11 is easily accessible via internet-based supplement vendors making… read more here.
Keywords: metabolism; selective androgen; receptor modulator; androgen receptor ... See more keywords
Simultaneous Quantification of Antidepressants and Metabolites in Urine and Plasma Samples by GC–MS for Therapeutic Drug Monitoring
Sign Up to like & getrecommendations! Published in 2017 at "Chromatographia"
DOI: 10.1007/s10337-017-3240-3
Abstract: The aim of this work was the optimization and method validation for antidepressants (fluoxetine, venlafaxine, amitriptyline, mianserin, trimipramine, nortriptyline, mirtazapine, sertraline, dothiepin, citalopram, and paroxetine) and their metabolites in urine and plasma samples using gas… read more here.
Keywords: plasma; method; urine plasma; simultaneous quantification ... See more keywords
Urine and plasma metabolomics study on potential hepatoxic biomarkers identification in rats induced by Gynura segetum.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.01.017
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Gynura segetum (GS) is an herbal medicine containing Pyrrolizidine Alkaloids (PAs) that causes hepatic sinusoidal obstruction syndrome (HSOS). AIM OF THE STUDY To discover potential biomarkers and metabolic mechanisms involved in the hepatotoxicity… read more here.
Keywords: metabolism; urine plasma; gynura segetum; hepatotoxicity ... See more keywords
Quantification of clofarabine in urine and plasma by LC-MS/MS: suitable for PK study and TDM in pediatric patients with relapsed or refractory ALL
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05843j
Abstract: Clofarabine is approved for the treatment of relapsed or refractory acute lymphoblastic leukemia (ALL) in pediatric patients aged 1 to 21 years. Its pharmacokinetic (PK) exposure is strongly related to clinical outcomes and high risk… read more here.
Keywords: pediatric patients; relapsed refractory; urine plasma; clofarabine urine ... See more keywords
P1457COMPARISON OF PEPTIDOMES BETWEEN URINE, PLASMA, AND HEMODIALYSIS FLUID INDICATES SELECTIVITY IN RENAL PEPTIDE PROCESSING
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p1457
Abstract: The physiological and related body fluids, urine, plasma and hemodialysis (HD) fluid spent dialysate (a mixture of technical HD fluid and patient´s ultrafiltrate) are rich biological sources of information especially in the context of kidney… read more here.
Keywords: urine plasma; spent dialysate; fluid; kidney ... See more keywords
Tenofovir-Diphosphate in Dried Blood Spots vs Tenofovir in Urine/Plasma for Oral Preexposure Prophylaxis Adherence Monitoring
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac405
Abstract: Abstract Background Tenofovir-diphosphate (TFV-DP) measured in dried blood spots (DBS) and tenofovir (TFV) measured in urine/plasma have been used to measure TFV-based oral pre-exposure prophylaxis (PrEP) adherence. However, there are limited data comparing these 3… read more here.
Keywords: adherence; tfv; dried blood; urine plasma ... See more keywords
Analysis of reactive aldehydes in urine and plasma of type-2 diabetes mellitus patients through liquid chromatography-mass spectrometry: Reactive aldehydes as potential markers of diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.997015
Abstract: Introduction Diabetes is a major public health issue that is approaching epidemic proportions globally. Diabetes mortality is increasing in all ethnic groups, irrespective of socio-economic class. Obesity is often seen as the main contributor to… read more here.
Keywords: reactive aldehydes; liquid chromatography; oxidative stress; plasma ... See more keywords
Initial Evaluation of Uroplakins UPIIIa and UPII in Selected Benign Urological Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11121816
Abstract: Background: Uroplakins (UPs) are glycoproteins that play a specific role in the structure and function of the urothelium. Disorders which affect the normal expression of UPs are associated with the pathogenesis of infections and neoplasms… read more here.
Keywords: initial evaluation; urinary tract; benign urological; urine plasma ... See more keywords
Untargeted Metabolomic Characterization of Ovarian Tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12123642
Abstract: Simple Summary This study utilized untargeted metabolomic techniques to detect urine and plasma metabolites. Using support vector machine algorithm, three models for ovarian tumors diagnosis, benign-malignant distinguishing, early diagnosis and borderline-malignant distinguishing were developed. These… read more here.
Keywords: ovarian tumors; diagnosis; untargeted metabolomic; urine plasma ... See more keywords