Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group
Sign Up to like & getrecommendations! Published in 2020 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-020-00301-w
Abstract: In light of the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (suPAR), a group of experts from the fields of intensive care medicine, emergency medicine, internal medicine and infectious… read more here.
Keywords: urokinase plasminogen; medicine; activator receptor; emergency ... See more keywords
Urokinase Plasminogen Activator Receptor-PET with 68Ga-NOTA-AE105: First Clinical Experience with a Novel PET Ligand.
Sign Up to like & getrecommendations! Published in 2017 at "PET clinics"
DOI: 10.1016/j.cpet.2017.02.003
Abstract: Urokinase plasminogen activator receptor (uPAR) is a key component in proteolysis and extracellular matrix degradation during cancer invasion and metastasis. uPAR overexpression is an important biomarker for aggressiveness in several solid tumors and provides independent… read more here.
Keywords: urokinase plasminogen; pet; nota ae105; 68ga nota ... See more keywords
Soluble urokinase plasminogen activator receptor in type 1 diabetic children, relation to vascular complications.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2019.06.001
Abstract: BACKGROUND Endothelial dysfunction caused by chronic inflammation is the cornerstone of vascular complications in type 1 Diabetes-Mellitus (T1DM). Soluble Urokinase Plasminogen Activator Receptor (SuPAR) is a novel marker of inflammation and endothelial dysfunction. AIM To… read more here.
Keywords: vascular complications; urokinase plasminogen; plasminogen activator; activator receptor ... See more keywords
Elevated preoperative suPAR is a strong and independent risk marker for postoperative complications in patients undergoing major noncardiac surgery (SPARSE).
Sign Up to like & getrecommendations! Published in 2021 at "Surgery"
DOI: 10.1016/j.surg.2021.10.012
Abstract: BACKGROUND Patients undergoing major surgery are often at risk of developing postoperative complications. We investigated whether a preoperative marker of chronic inflammation, soluble urokinase plasminogen activator receptor, can aid in identifying patients at high risk… read more here.
Keywords: urokinase plasminogen; plasminogen activator; soluble urokinase; activator receptor ... See more keywords
Cardiac macrophages adopt profibrotic/M2 phenotype in infarcted hearts: Role of urokinase plasminogen activator.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2016.05.016
Abstract: BACKGROUND Macrophages (mac) that over-express urokinase plasminogen activator (uPA) adopt a profibrotic M2 phenotype in the heart in association with cardiac fibrosis. We tested the hypothesis that cardiac macs are M2 polarized in infarcted mouse… read more here.
Keywords: phenotype; cardiac macs; urokinase plasminogen; heart ... See more keywords
Urokinase Plasminogen Activator Receptor-Mediated Targeting of a Stable Nanocomplex Coupled with Specific Peptides for Imaging of Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c02697
Abstract: Targeting peptides are a promising tool for early diagnosis and therapy of cancer. Overexpression of urokinase plasminogen activator receptor (uPAR) leads to the progression of tumors including prostate, colorectal, ovarian, and breast cancers. To improve… read more here.
Keywords: urokinase plasminogen; microscopy; activator receptor; spectroscopy ... See more keywords
Guiding oligodendrocyte precursor cell maturation with urokinase plasminogen activator-degradable elastin-like protein hydrogels.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c00828
Abstract: Demyelinating injuries and diseases, like multiple sclerosis, affect millions of people worldwide. Oligodendrocyte precursor cells (OPCs) have the potential to repair demyelinated tissue because they can both self-renew and differentiate into oligodendrocytes (OLs), the myelin… read more here.
Keywords: urokinase plasminogen; plasminogen activator; upa degradable; maturation ... See more keywords
Engineered Antibody Fragment against the Urokinase Plasminogen Activator for Fast Delineation of Triple-Negative Breast Cancer by Positron Emission Tomography.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c01139
Abstract: The urokinase plasminogen activator (uPA) and its cofactors are important regulators of tumor initiation and progression (including metastasis), and its overexpression is associated with unfavorable situations in cancer patients. We have previously used positron emission… read more here.
Keywords: urokinase plasminogen; antibody; atn 291; positron emission ... See more keywords
Recent Advances in Targeting the Urokinase Plasminogen Activator with Nanotherapeutics.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00055
Abstract: The aberrant proteolytic landscape of the tumor microenvironment is a key contributor of cancer progression. Overexpression of urokinase plasminogen activator (uPA) and/or its associated cell-surface receptor (uPAR) in tumor versus normal tissue is significantly associated… read more here.
Keywords: plasminogen activator; tumor; urokinase plasminogen; recent advances ... See more keywords
Soluble urokinase plasminogen activator receptor (suPAR) predicts critical illness and kidney failure in patients admitted to the intensive care unit
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96352-1
Abstract: Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker and risk factor for kidney diseases, with a potential prognostic value in critically ill patients. In this monocentric prospective study, we measured plasma suPAR levels… read more here.
Keywords: sofa score; urokinase plasminogen; supar; plasminogen activator ... See more keywords
Soluble urokinase plasminogen activator receptor and functionally relevant coronary artery disease: a prospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2038269
Abstract: Abstract Background Soluble urokinase plasminogen activator receptor (suPAR) is an emerging biomarker associated with anatomical CAD burden and cardiovascular outcomes including myocardial infarction (MI) and death. We aimed to validate previous findings of the prognostic… read more here.
Keywords: urokinase plasminogen; activator receptor; plasminogen activator; death ... See more keywords