Urological Cancers and Kidney Transplantation: a Literature Review
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DOI: 10.1007/s11934-021-01078-2
Abstract: The aim of this review is to provide an overview of epidemiology, risk factors, and treatment of urological malignancies in renal transplant recipients (RTR). Although optimal immunosuppressive therapy and cancer management in these patients remain… read more here.
Keywords: urological cancers; literature review; transplantation literature; kidney transplantation ... See more keywords
Personalized peptide vaccines and their relation to other therapies in urological cancer
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DOI: 10.1038/nrurol.2017.77
Abstract: Immunotherapy is an important therapeutic modality for urological cancers and several immunological agents for their treatment, such as sipuleucel-T and immune checkpoint inhibitors, have been approved by the FDA. Personalized peptide vaccines (PPVs) are an… read more here.
Keywords: personalized peptide; peptide vaccines; vaccines relation; urological cancers ... See more keywords
Patient-derived tumour models for personalized therapeutics in urological cancers
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Urology"
DOI: 10.1038/s41585-020-00389-2
Abstract: Preclinical knowledge of dysregulated pathways and potential biomarkers for urological cancers has undergone limited translation into the clinic. Moreover, the low approval rate of new anticancer drugs and the heterogeneous drug responses in patients indicate… read more here.
Keywords: derived tumour; tumour models; patient derived; oncology ... See more keywords
The Prognostic Value of Platelet-to-Lymphocyte Ratio in Urological Cancers: A Meta-Analysis
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DOI: 10.1038/s41598-017-15673-2
Abstract: The relationship of platelet-to-lymphocyte ratio (PLR) and survival in urological cancers remained inconsistent in previous studies. Therefore, we performed a meta-analysis to assess the prognostic significance of PLR in patients with urological cancers. A literature… read more here.
Keywords: patients urological; platelet lymphocyte; lymphocyte ratio; urological cancers ... See more keywords
Biomarkers for immunotherapy in urological cancers
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DOI: 10.1097/mou.0000000000000465
Abstract: Purpose of review Immunotherapies for urological malignancies have made tremendous progress by targeting immune checkpoints and have been implemented in clinical practice nowadays. Though siginifcant number of patients does not respond to immunotherapy. Biomarkers could… read more here.
Keywords: urology; immunotherapy urological; urological cancers; biomarkers immunotherapy ... See more keywords
The burden of urological cancers in low‐ and middle‐income countries
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DOI: 10.1111/bju.14641
Abstract: T he burden of cancer in lowand middle-income countries (LMICs) continues to rise [1]. Evaluation of geographical differences in cancer mortality statistics is specifically of interest in LMICs as (inter)national guidelines are potentially less embedded… read more here.
Keywords: middle income; burden urological; urological cancers; cancer ... See more keywords
Boron neutron capture therapy for urological cancers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Urology"
DOI: 10.1111/iju.14855
Abstract: Boron neutron capture therapy is based on a nuclear reaction between the nonradioactive isotope boron‐10 and either low‐energy thermal neutrons or high‐energy epithermal neutrons, which generate high linear energy transfer α particles and a recoiled… read more here.
Keywords: urological cancers; neutron capture; boron neutron; capture therapy ... See more keywords
Genomic landscape of treatment‐naïve urological cancers using next‐generation sequencing‐based panel test in the Japanese population
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Urology"
DOI: 10.1111/iju.14927
Abstract: The top three urologic cancers in terms of mortality are PC (3.8%), bladder cancer (2.1%), and kidney cancer (2.1%) among all cancers in 2020. 1 The determination of therapeutic sensi-tivity based on genomic alteration has… read more here.
Keywords: genomic alterations; landscape; urological cancers; treatment ... See more keywords
Diagnostic and prognostic biomarkers of common urological cancers based on aberrant DNA methylation.
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DOI: 10.2217/epi-2018-0017
Abstract: AIM We intended to construct DNA methylation-based models for the diagnosis and prognosis of three common urological cancers including prostate adenocarcinoma, renal clear cell carcinoma and bladder urothelial carcinoma. MATERIALS & METHODS Total 450K methylation array… read more here.
Keywords: methylation; carcinoma; common urological; urological cancers ... See more keywords
The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.850145
Abstract: Overproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with the detoxification of ROS-mediated lipid peroxidation-generated reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE), malondialdehyde, and… read more here.
Keywords: potential role; dehydrogenase; cellular senescence; urological cancers ... See more keywords
Prognostic Role of Pretreatment De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase Ratio) in Urological Cancers: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01650
Abstract: Background: To examine the potential prognostic significance of pretreatment De Ritis ratio (aspartate transaminase/alanine transaminase ratio) in urological cancers, including upper tract urothelial cancer (UTUC), renal cell carcinoma (RCC), prostate cancer (PCa), bladder cancer (BCa).… read more here.
Keywords: ratio; pretreatment ritis; urological cancers; transaminase ... See more keywords