Phase II study (KAMELEON) of single-agent T-DM1 in patients with HER2-positive advanced urothelial bladder cancer or pancreatic cancer/cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5893
Abstract: The antibody-drug conjugate trastuzumab emtansine (T-DM1) is approved for human epidermal growth factor receptor 2 (HER2/ERBB2)-positive breast cancer. We aimed to study tumor HER2 expression and its effects on T-DM1 responses in patients with HER2-positive… read more here.
Keywords: cancer; patients her2; urothelial bladder; her2 positive ... See more keywords
Haplotype‐based association of Vascular Endothelial Growth Factor gene polymorphisms with urothelial bladder cancer risk in Tunisian population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22610
Abstract: Accumulated data suggested that Vascular Endothelial Growth Factor is a major mediator in vasculogenesis, angiogenesis and recently in tumorigenesis. Therefore, we aimed to investigate for the first time the association between VEGF gene variants (‐2549I/D… read more here.
Keywords: bladder cancer; tunisian population; urothelial bladder; vascular endothelial ... See more keywords
Oncological impact of inflammatory biomarkers in elderly patients treated with radical cystectomy for urothelial bladder cancer
Sign Up to like & getrecommendations! Published in 2020 at "Arab Journal of Urology"
DOI: 10.1080/2090598x.2020.1814974
Abstract: ABSTRACT Objective To evaluate the impact of preoperative markers of systemic inflammation on complications and oncological outcomes in patients aged ≥75 years treated with radical cystectomy (RC) for urothelial bladder cancer (UBC). Patients and methods… read more here.
Keywords: urothelial bladder; bladder cancer; radical cystectomy; cancer ... See more keywords
Non‐invasive diagnosis and monitoring of urothelial bladder cancer: are we there yet?
Sign Up to like & getrecommendations! Published in 2019 at "BJU International"
DOI: 10.1111/bju.14877
Abstract: gaps in our knowledge, but also raise many questions. What are the reasons that one-quarter of patients with CPPS did not experience flares and what can we learn from this specific subgroup to optimize our… read more here.
Keywords: invasive diagnosis; monitoring urothelial; cpps flares; urothelial bladder ... See more keywords
Strong Expression of Cancertestis Antigens CTAG1B and MAGEA3 Is Correlated with Unfavourable Histopathological Features and MAGEA3 Is Associated with Worse Progression-Free Survival in Urothelial Bladder Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Urologia Internationalis"
DOI: 10.1159/000493577
Abstract: Background: Cancer/testis antigens (CTA) are expressed in urothelial bladder cancer (UBC). Their therapeutical and prognostic relevance remains unclear. We studied the correlation of MAGEA3 and CTAG1B with histopathological factors in UBC and their prognostic value.… read more here.
Keywords: correlated unfavourable; magea3; urothelial bladder; expression ... See more keywords
Neoadjuvant immunotherapy for muscle invasive urothelial bladder carcinoma: will it change current standards?
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Advances in Urology"
DOI: 10.1177/17562872211029779
Abstract: Immunotherapy, in the form of immune checkpoint inhibitors (ICI), has shown activity in metastatic urothelial bladder carcinoma, resulting in the approval of several ICI agents in the first- and second-line settings. This has led to… read more here.
Keywords: bladder carcinoma; muscle invasive; urothelial bladder;
Molecular subtyping of metastatic urothelial bladder cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.6_suppl.326
Abstract: 326Background: TCGA molecular sybtyping is established in metastatic urothelial bladder cancer (UBC). It remains unclear if it is of prognostic importance with chemotherapy in metastatic UBC. Data into immune therapy suggests TCGA subtyping is predictive… read more here.
Keywords: bladder cancer; urothelial bladder; molecular subtyping; cancer ... See more keywords
Adding mitomycin to Bacillus Calmette-Guérin as adjuvant intravesical therapy for high-risk, nonmuscle-invasive urothelial bladder cancer (BCGMM; ANZUP 1301).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.tps602
Abstract: TPS602Background: Adjuvant intravesical bacillus Calmette-Guerin (BCG) decreases disease recurrence and progression in people with high-risk, non-muscle invasive urothelial bladder cancer (NMIBC), ... read more here.
Keywords: bladder cancer; invasive urothelial; urothelial bladder; high risk ... See more keywords
LncRNA CCHE1 Participates in the Postoperative Distant Recurrence of Urothelial Bladder Cancer Possibly by Regulating ROCK1 Expression.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2022039524
Abstract: LncRNA CCHE1 has been functionally characterized as a critical player in multiple cancers. However, its role in urothelial bladder cancer (UBC) is unclear. Therefore, our study aimed to investigate its role in UBC. In our… read more here.
Keywords: distant recurrence; expression; cche1; recurrence ... See more keywords
The Association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients.
Sign Up to like & getrecommendations! Published in 2022 at "Bosnian journal of basic medical sciences"
DOI: 10.17305/bjbms.2021.6767
Abstract: Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis. The aim was… read more here.
Keywords: expression; outcome; bladder cancer; urothelial bladder ... See more keywords
Identification of key genes and microRNA regulatory network in development and progression of urothelial bladder carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Translational andrology and urology"
DOI: 10.21037/tau-20-1124
Abstract: Background Bladder cancer as other cancers contains multiple dynamic alterations in progression. Theoretically, large number of genes participates in cancer progression. In the present study, the interconnections of genesets defined by Gene Set Enrichment Analysis… read more here.
Keywords: bladder cancer; urothelial bladder; progression; bladder carcinoma ... See more keywords