Genome‐wide aneuploidy detected by mFast‐SeqS in circulating cell‐free DNA is associated with poor response to pembrolizumab in patients with advanced urothelial cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13196
Abstract: Second‐line treatment with immune checkpoint inhibition in patients with metastatic urothelial cancer (mUC) has a low success rate (~ 20%). Circulating tumour‐derived DNA (ctDNA) levels may guide patient stratification, provided that an affordable and robust assay… read more here.
Keywords: mfast seqs; urothelial cancer; seqs; response ... See more keywords
Impact of performance status on treatment outcomes: A real‐world study of advanced urothelial cancer treated with immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32645
Abstract: Immune checkpoint inhibitors (ICIs) represent an appealing treatment for patients with advanced urothelial cancer (aUC) and a poor performance status (PS). However, the benefit of ICIs for patients with a poor PS remains unknown. It… read more here.
Keywords: immune checkpoint; performance status; urothelial cancer; checkpoint inhibitors ... See more keywords
Noninvasive diagnosis of urothelial cancer in urine using DNA hypermethylation signatures—Gender matters
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DOI: 10.1002/ijc.32356
Abstract: Urothelial cancer (UCa) is the most predominant cancer of the urinary tract and noninvasive diagnosis using hypermethylation signatures in urinary cells is promising. Here, we assess gender differences in a newly identified set of methylation… read more here.
Keywords: methylation; urothelial cancer; hypermethylation; noninvasive diagnosis ... See more keywords
Pembrolizumab versus chemotherapy in recurrent, advanced urothelial cancer in Japanese patients: a subgroup analysis of the phase 3 KEYNOTE-045 trial
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-019-01545-4
Abstract: Background The open-label, randomized, active-controlled KEYNOTE-045 study (NCT02256436) showed that second-line pembrolizumab significantly improved overall survival (OS) of patients with advanced/metastatic urothelial cancer (UC) that progressed after first-line platinum-containing chemotherapy, compared with standard chemotherapy (paclitaxel,… read more here.
Keywords: chemotherapy; keynote 045; urothelial cancer; japanese patients ... See more keywords
Expressions of PD-L1 and Nectin-4 in urothelial cancer patients treated with pembrolizumab
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02717-3
Abstract: Recently, the standard of care for advanced urothelial cancer (UC) has been changed by developing immune-checkpoint inhibitors (ICIs). However, its response rate is limited to 20–30%. The identification of biomarkers to predict the therapeutic effects… read more here.
Keywords: urothelial cancer; patients treated; treated pembrolizumab; tumor cells ... See more keywords
Guillain‐Barré Syndrome Related to Nivolumab: Case Report of a Patient With Urothelial Cancer and Review of the Literature
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Genitourinary Cancer"
DOI: 10.1016/j.clgc.2018.11.022
Abstract: Immunotherapy with the use of immune checkpoint inhibitors has emerged as a new pillar in cancer therapeutics. Nivolumab is an antibody targeting programmed cell death 1 (PD-1) signaling, which is approved for urothelial cancer treatment… read more here.
Keywords: immune checkpoint; related nivolumab; urothelial cancer; case ... See more keywords
Upper tract urothelial cancer.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2017.10.021
Abstract: While urothelial carcinoma is a very common tumor, involvement of the upper tract is relatively uncommon. Consequently, there are no consensus imaging recommendations for upper tract disease. CT urography is the dominant imaging modality for… read more here.
Keywords: urothelial cancer; upper tract; tract urothelial; tract ... See more keywords
Integrative Clinical and Genomic Characterization of MTAP-deficient Metastatic Urothelial Cancer.
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DOI: 10.1016/j.euo.2021.10.006
Abstract: Deficiency of MTAP (MTAPdef) mainly occurs because of homozygous loss of chromosome 9p21, which is the most common copy-number loss in metastatic urothelial cancer (mUC). We characterized the clinical and genomic features of MTAPdef mUC… read more here.
Keywords: urothelial cancer; mtap; biology; cancer ... See more keywords
Immune Checkpoint Inhibition in Metastatic Urothelial Cancer.
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DOI: 10.1016/j.eururo.2017.03.047
Abstract: Immune checkpoint inhibitors are a new treatment option in metastatic urothelial cancer on the basis of available phase 2 and 3 trials. Predictive biomarkers are needed. These should go beyond PD-L1 expression, which is showing… read more here.
Keywords: checkpoint inhibition; immune checkpoint; metastatic urothelial; urothelial cancer ... See more keywords
The effect of acyl chain length and saturation on the interactions of pirarubicin with phosphatidylethanolamines in 2D model urothelial cancer cell membranes
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DOI: 10.1016/j.molliq.2020.114633
Abstract: Abstract The interactions of an anticancer drug pirarubicin (THP) with a series of phosphatidylethanolamine (PE) lipids differing in the length and unsaturation degree of acyl chains were investigated using the Langmuir technique supplemented with Brewster… read more here.
Keywords: urothelial cancer; thp; cell membranes; drug ... See more keywords
Dose-Dependent Response to 3-Nitrobenzanthrone Exposure in Human Urothelial Cancer Cells.
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DOI: 10.1021/acs.chemrestox.7b00174
Abstract: A product of incomplete combustion of diesel fuel, 3-nitrobenzanthrone (3-NBA), has been classified as a cancer-causing substance. It first gained attention as a potential urinary bladder carcinogen due to the presence of its metabolite in… read more here.
Keywords: urothelial cancer; response; human urothelial; exposure ... See more keywords