Evidence‐based adequacy criteria for instrumented urine cytology using cytospin preparations
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.23890
Abstract: Cytospin preparations of instrumented urine cytology specimens with less than 10 urothelial cells or more than 50 urothelial cells/10 hpfs are both associated with significantly increased false negative rates compared to cases with 10‐49 urothelial… read more here.
Keywords: evidence based; urothelial cells; instrumented urine; urine cytology ... See more keywords
2‐mercaptobenzothiazole generates γ‐H2AX via CYP2E1‐dependent production of reactive oxygen species in urothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23043
Abstract: Ortho (o)‐toluidine is a widely known carcinogenic substance associated with cancers of the human bladder. A study on British chemical factory workers exposed to 2‐mercaptobenzothiazole, phenyl‐β‐naphthylamine, aniline, and o‐toluidine demonstrated the crucial roles of o‐toluidine,… read more here.
Keywords: reactive oxygen; oxygen species; mercaptobenzothiazole generates; urothelial cells ... See more keywords
LPS‐mediated release of ATP from urothelial cells occurs by lysosomal exocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24377
Abstract: While numerous studies have confirmed ATP's importance in bladder physiology/pathophysiology, the literature is still conflicted regarding the mechanism of ATP release from the urothelium. Multiple mechanisms have been identified including non‐vesicular release via pannexin channels… read more here.
Keywords: atp urothelial; release atp; urothelial cells; lps mediated ... See more keywords
Differentiation-dependent rearrangements of actin filaments and microtubules hinder apical endocytosis in urothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-017-1566-4
Abstract: During differentiation, superficial urothelial cells (UCs) of the urinary bladder form the apical surface, which is almost entirely covered by urothelial plaques containing densely packed uroplakin particles. These urothelial plaques are the main structural components… read more here.
Keywords: differentiated ucs; apical endocytosis; endocytosis; urothelial cells ... See more keywords
Gemcitabine: Selective cytotoxicity, induction of inflammation and effects on urothelial function
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2016.12.011
Abstract: Abstract Intravesical gemcitabine has recently been introduced for the treatment of superficial bladder cancer and has a favourable efficacy and toxicity profile in comparison to mitomycin c (MMC), the most commonly used chemotherapeutic agent. The… read more here.
Keywords: gemcitabine; cell lines; urothelial function; urothelial cells ... See more keywords
Purinergic receptor mediated calcium signalling in urothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52531-9
Abstract: Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the… read more here.
Keywords: atp; urothelial cells; purinergic receptor; calcium ... See more keywords
Pharmacodynamics of D-mannose in the prevention of recurrent urinary infections
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2022.2061184
Abstract: Abstract Recurring urinary tract infections (rUTIs) are frequently caused by Escherichia coli, which invades urothelial cells and forms quiescent bacterial reservoirs. D-mannose, an inert monosaccharide, represents a notable agent for rUTI prevention; however, there is… read more here.
Keywords: mannose prevention; pharmacodynamics mannose; recurrent urinary; prevention ... See more keywords
MP28-19 NOX-DERIVED SUPEROXIDE PRODUCTION IN BLADDER UROTHELIUM: EFFECT OF AGING AND HUMAN STUDY
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000867.019
Abstract: thoroughly characterize mouse bladder urothelium. METHODS: 18,917 single cells from C57BL/6 mouse bladder urothelium was analyzed by unbiased single-cell RNA sequencing to classify bladder cell types and their underlying functions. RESULTS: Clustering analysis identified 8… read more here.
Keywords: bladder urothelium; urothelial cells; mouse bladder; bladder urothelial ... See more keywords
Expression of components of the urothelial cholinergic system in bladder and cultivated primary urothelial cells of the pig
Sign Up to like & getrecommendations! Published in 2019 at "BMC Urology"
DOI: 10.1186/s12894-019-0495-z
Abstract: BackgroundPorcine urinary bladders are widely used for uro-pharmacological examinations due to their resemblance to the human organ. However, characterisations of the porcine urothelium at the molecular level are scarce up to now. As it has… read more here.
Keywords: primary urothelial; cultivated primary; bladder; urothelial cells ... See more keywords
Detection of cytological abnormalities in urothelial cells from individuals previously exposed or currently infected with Schistosoma haematobium
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0278202
Abstract: Urinary schistosomiasis has long been associated with bladder cancer, but it is still not clear the mechanisms involved. Schistosoma haematobium causes injury and disruptions in the integrity of the urothelium. The cellular and immunologic responses… read more here.
Keywords: schistosoma haematobium; urothelial cells; schistosomiasis; haematobium ... See more keywords
Generation of Urothelial Cells from Mouse-Induced Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc21250
Abstract: Background and Objectives The search for a suitable alternative for urethral defect is a challenge in the field of urethral tissue engineering. Induced pluripotent stem cells (iPSCs) possess multipotential for differentiation. The in vitro derivation… read more here.
Keywords: pluripotent stem; urothelial cells; induced pluripotent; differentiation ... See more keywords