Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1965
Abstract: It has been previously reported that ursodeoxycholic acid (UDCA), a therapeutic bile acid, reduced risk for advanced colorectal adenoma in men but not women. Interactions between the gut microbiome and fecal bile acid composition as… read more here.
Keywords: ursodeoxycholic acid; microbial community; composition; gut microbiome ... See more keywords
Pharmacokinetics and Pharmacodynamics of Ursodeoxycholic Acid in an Overweight Population With Abnormal Liver Function
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.790
Abstract: Ursodeoxycholic acid (UDCA) is a secondary bile acid that is used to treat primary biliary cholangitis. Although UDCA has a hepatoprotective effect in some diseases, its benefit in nonalcoholic fatty liver disease (NAFLD) remains controversial.… read more here.
Keywords: liver function; udca 300; ursodeoxycholic acid; twice daily ... See more keywords
Effect of ursodeoxycholic acid on gallstone formation after bariatric surgery: An updated meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23427
Abstract: Bariatric surgery increases the risk of postoperative gallstone formation. Many studies have proposed ursodeoxycholic acid (UDCA) as a preventive agent for postoperative gallstone formation. This study aimed to investigate the effect of UDCA on gallstone… read more here.
Keywords: bariatric surgery; ursodeoxycholic acid; gallstone formation; gallstone ... See more keywords
Occurrence of Jaundice Following Simultaneous Ursodeoxycholic Acid Cessation and Obeticholic Acid Initiation
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4900-8
Abstract: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic disease for which ursodeoxycholic acid (UDCA) has been the mainstay of treatment. Obeticholic acid (OCA) emerged in 2016 as a second agent for PBC treatment. It… read more here.
Keywords: initiation; ursodeoxycholic acid; jaundice; obeticholic acid ... See more keywords
The Role of Ursodeoxycholic Acid (UDCA) in Cholelithiasis Management After One Anastomosis Gastric Bypass (OAGB) for Morbid Obesity: Results of a Monocentric Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2020 at "Obesity Surgery"
DOI: 10.1007/s11695-020-04801-z
Abstract: Bariatric surgery leads to rapid weight loss, a well-known risk factor for gallstone formation. Postoperative biliary complication rate requiring cholecystectomy is between 0.9 and 7.5% after laparoscopic sleeve gastrectomy and between 6 and 50% after… read more here.
Keywords: bypass; gastric bypass; acid udca; cholelithiasis ... See more keywords
Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.
Sign Up to like & getrecommendations! Published in 2017 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2016.12.003
Abstract: BACKGROUND AND AIMS In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling,… read more here.
Keywords: airway remodelling; ursodeoxycholic acid; apoptosis; effects ursodeoxycholic ... See more keywords
Ursodeoxycholic acid alleviates nonalcoholic fatty liver disease by inhibiting apoptosis and improving autophagy via activating AMPK.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.128
Abstract: Ursodeoxycholic acid (UDCA), first identified in bear bile, was widely used in cholestatic liver diseases. Our previous studies have suggested UDCA may exert favorable influence on hepatic steatosis. However, the molecular mechanism remains elusive. Given… read more here.
Keywords: autophagy apoptosis; fatty liver; ursodeoxycholic acid; apoptosis ... See more keywords
Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.009
Abstract: Lipopolysaccharide (LPS) from Gram (-) bacteria induces inflammatory cholestasis by impairing the expression/localization of transporters involved in bile formation (e.g., Bsep, Mrp2). Therapeutic options for this disease are lacking. Ursodeoxycholic acid (UDCA) is the first… read more here.
Keywords: plasma; ursodeoxycholic acid; expression; bsep ... See more keywords
Ursodeoxycholic acid protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis in MPTP/MPP+-induced Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135493
Abstract: Neuroprotection targeting mitochondrial dysfunction has been proposed as a potential therapeutic strategy for Parkinson's disease (PD). Ursodeoxycholic acid (UDCA) has been shown to prevent neuronal damage; however, the role of UDCA in PD is poorly… read more here.
Keywords: mpp; mptp; mptp mpp; ursodeoxycholic acid ... See more keywords
An effective synthesis of ursodeoxycholic acid from dehydroepiandrosterone
Sign Up to like & getrecommendations! Published in 2021 at "Steroids"
DOI: 10.1016/j.steroids.2021.108870
Abstract: A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from plant-source dehydroepiandrosterone (DHEA), with a Mistunobu reaction and regioselective allyl oxidationat as the key steps. The reaction conditions of the… read more here.
Keywords: effective synthesis; ursodeoxycholic acid; synthesis ursodeoxycholic; dehydroepiandrosterone ... See more keywords
Ursodeoxycholic acid protects interstitial Cajal-like cells in the gallbladder from undergoing apoptosis by inhibiting TNF-α expression
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.206
Abstract: Hypomotility is a common symptom of gallstone disease, which is accompanied by a loss of interstitial Cajal-like cells (ICLCs) in the gallbladder. Ursodeoxycholic acid (UDCA) is widely used in treating gallstone disease, and has shown… read more here.
Keywords: gallbladder undergoing; ursodeoxycholic acid; interstitial cajal; cajal like ... See more keywords