Synthesis and antitumor potential of new arylidene ursolic acid derivatives via caspase‐8 activation
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DOI: 10.1002/ardp.202000448
Abstract: Continuing our studies on NO‐donating ursolic acid–benzylidene derivatives as potential antitumor agents, we designed and synthesized a series of new arylidene derivatives containing NO‐donating ursolic acid and aromatic heterocyclic units. Compounds 5c and 6c showed… read more here.
Keywords: new arylidene; ursolic acid; caspase activation;
Advances in production and structural derivatization of the promising molecule ursolic acid.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology journal"
DOI: 10.1002/biot.202000657
Abstract: BACKGROUND Ursolic acid (UA) is a ursane-type pentacyclic triterpenoid compound, naturally produced in plants via specialized metabolism and exhibits vast range of remarkable physiological activities and pharmacological manifestations. Owing to significant safety and efficacy in… read more here.
Keywords: structural derivatization; production; ursolic acid; advances production ... See more keywords
Ursolic acid silences CYP19A1/aromatase to suppress gastric cancer growth
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DOI: 10.1002/cam4.4536
Abstract: Gastric cancer (GCa) is a malignancy with few effective treatments. Ursolic acid (UA), a bioactive triterpenoid enriched in Hedyotis diffusa Willd, known to suppress GCa without identified target. CYP19A1 (cytochrome P450 family 19A1; also known… read more here.
Keywords: cyp19a1 aromatase; ursolic acid; gastric cancer; acid silences ... See more keywords
Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23032
Abstract: Ursolic acid (UA) has been shown to suppress various tumor progression, however, its roles in Adriamycin resistance of human ovarian cancer (OC) cells are still unclear. This work aims to investigate the effects of UA… read more here.
Keywords: skov3; ursolic acid; hur; resistance ... See more keywords
Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids
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DOI: 10.1007/s00044-019-02344-2
Abstract: As pharmacophore hybridization has been used frequently in the discovery of new drugs, ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids have been synthesized and evaluated their antiproliferative activity by the MTT assay. The results displayed that, the hybrids… read more here.
Keywords: thymine hybrids; glycyrrhetinic acid; ursolic acid; acid ... See more keywords
Synthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety
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DOI: 10.1007/s00044-019-02349-x
Abstract: Three series of ursolic acid derivatives containing an aminoguanidine moiety were designed, synthesized, and evaluated for anti-bacterial and anti-inflammatory activity. Some compounds displayed potent anti-bacterial activity against Gram-positive bacterial strains (including multidrug-resistant clinical isolates) and… read more here.
Keywords: containing aminoguanidine; aminoguanidine moiety; ursolic acid; derivatives containing ... See more keywords
Synthesis and cytotoxic evaluation of malachite green derived oleanolic and ursolic acid piperazineamides
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DOI: 10.1007/s00044-020-02536-1
Abstract: The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid with meta or para substituted carboxylated malachite green analogs gave conjugates 10 , 11 , 15 , and 16 that were cytotoxic for… read more here.
Keywords: ursolic acid; malachite green; cytotoxic evaluation; synthesis cytotoxic ... See more keywords
Multi-omics integration reveals the hepatoprotective mechanisms of ursolic acid intake against chronic alcohol consumption
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DOI: 10.1007/s00394-021-02632-x
Abstract: Alcoholic liver disease (ALD) is a major health issue globally. In addition to pharmacotherapy, dietary support is also regarded as reliable strategy for ALD management. As a widely distributed natural constituent within edible plants, the… read more here.
Keywords: integration; alcoholic liver; ursolic acid; liver injury ... See more keywords
Oleanolic acid and ursolic acid as potential inhibitors of human salivary α-amylase: insights from in vitro assays and in silico simulations
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DOI: 10.1007/s00894-017-3416-7
Abstract: AbstractIt is known that inhibiting α-amylase, an important enzyme in digestion of starch and glycogen, is a useful strategy for treating disorders in carbohydrate uptake. Two natural components distributed in many fruits and plants, oleanolic… read more here.
Keywords: oleanolic acid; acid ursolic; human salivary; ursolic acid ... See more keywords
Protective Effects of Ursolic Acid Against Cytotoxicity Induced by Corticosterone: Role of Protein Kinases
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DOI: 10.1007/s11064-019-02906-1
Abstract: Neuronal hippocampal death can be induced by exacerbated levels of cortisol, a condition usually observed in patients with Major depressive disorder (MDD). Previous in vitro and in vivo studies showed that ursolic acid (UA) elicits… read more here.
Keywords: induced corticosterone; protein; ursolic acid; cytotoxicity ... See more keywords
Evolution from small molecule to nano-drug delivery systems: An emerging approach for cancer therapy of ursolic acid
Sign Up to like & getrecommendations! Published in 2020 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2020.03.001
Abstract: Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application. Recently, with the development of… read more here.
Keywords: cancer; ursolic acid; delivery systems; cancer therapy ... See more keywords