Effects of a State‐ and Use‐Dependent Nav1.7 Channel Blocker on Ambulatory Blood Pressure: A Randomized, Controlled Crossover Study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1298
Abstract: Vixotrigine is a state‐ and use‐dependent Nav1.7 channel blocker being investigated for the treatment of neuropathic pain conditions. This randomized, double‐blind, placebo‐controlled crossover trial was designed to evaluate changes in blood pressure with the administration… read more here.
Keywords: study; blood pressure; use dependent; state use ... See more keywords
Consequences of acute Nav1.1 exposure to deltamethrin
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2016.12.005
Abstract: Background: Pyrethroid insecticides are the most popular class of insecticides in the world, despite their near‐ubiquity, their effects of delaying the onset of inactivation of voltage‐gated sodium (Nav) channels have not been well‐evaluated in all… read more here.
Keywords: deltamethrin; exposure; use dependent; modification nav1 ... See more keywords
Dissociable use-dependent processes for volitional goal-directed reaching
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2022.0415
Abstract: Repetition of specific movement biases subsequent actions towards the practiced movement, a phenomenon known as use-dependent learning (UDL). Recent experiments that impose strict constraints on planning time have revealed two sources of use-dependent biases, one… read more here.
Keywords: dissociable use; processes volitional; use dependent; dependent processes ... See more keywords
Use‐dependent directional bias does not transfer to the untrained limb during bimanual contractions
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13769
Abstract: Skills learned through practice with one limb can often be transferred to the untrained limb. In the present report, we sought to determine whether movement direction biases, acquired through repeated movement with one limb, transfer… read more here.
Keywords: movement; limb; transfer untrained; untrained limb ... See more keywords
THAR SHE BLOWS! The Search for the Great Spermine Whale of Carbamazepine Resistance
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Currents"
DOI: 10.1177/1535759718822034
Abstract: Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy Beckonert NM, Opitz T, Pitsch J, Soares da Silva P, Beck H. J Neurosci. 2018;38(24):5596-5605. https://doi.org/10.1523/JNEUROSCI.0640-18.2018. Despite the development of… read more here.
Keywords: epilepsy; mechanism; use dependent; pharmacoresistance ... See more keywords
Simulation test for impartment of use-dependent plasticity by inactivation of axonal potassium channels on hippocampal mossy fibers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1154910
Abstract: Modification of axonal excitability directly impacts information transfer through the neuronal networks in the brain. However, the functional significance of modulation of axonal excitability by the preceding neuronal activity largely remains elusive. One remarkable exception… read more here.
Keywords: inactivation axonal; use dependent; mossy fibers; hippocampal mossy ... See more keywords