Reversion Mutations with Clinical Use of PARP Inhibitors: Many Genes, Many Versions.
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DOI: 10.1158/2159-8290.cd-17-0734
Abstract: Reversion mutations associated with PARP inhibitor resistance have been identified in tumors with RAD51C, RAD51D, and PALB2 as well as BRCA1 and BRCA2 mutations. Multiple different reversion mutations can occur in a single patient, and… read more here.
Keywords: parp inhibitors; clinical use; use parp; related article ... See more keywords
Analysis Suggests Wider Use for PARP Inhibitors.
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DOI: 10.1158/2159-8290.cd-nb2017-049
Abstract: Researchers have developed a new tool, HRDetect, to pinpoint tumors that display BRCA deficiency but don't harbor BRCA1/2 mutations. Evaluating their method in breast, ovarian, and pancreatic cancers, they identified patients whose tumors were potentially… read more here.
Keywords: parp inhibitors; use parp; wider use; analysis suggests ... See more keywords
Use of PARP inhibitors in prostate cancer: from specific to broader application
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1164067
Abstract: Prostate cancer (PC) is one of the major health issues of elderly men in the word. It is showed that there were approximately 1.414 million patients with PC in 2020 worldwide, with a high mortality… read more here.
Keywords: prostate cancer; use parp; parp inhibitors; cancer ... See more keywords