Insertion of Small Flexible Linkers as a Useful Scaffold Hopping Tool in Agrochemistry.
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DOI: 10.1021/acs.jafc.1c07971
Abstract: Inserting small flexible linkers of only one- to three-atom chain lengths into a molecular backbone is an important scaffold hopping manipulation. Analogues derived from biologically active compounds through the utilization of such a strategy are… read more here.
Keywords: useful scaffold; scaffold hopping; small flexible; insertion small ... See more keywords
Reversal of Functional Groups as a Useful Scaffold Hopping Tool in Agrochemistry.
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DOI: 10.1021/acs.jafc.1c08009
Abstract: Reverting the orientation of a functional group by exchanging molecular parts of it is an important scaffold hopping manipulation, as biologically active compounds and their analogs, which underwent such a transformation, are often similar in… read more here.
Keywords: useful scaffold; reversal functional; functional groups; hopping tool ... See more keywords
Isosteric Ring Exchange as a Useful Scaffold Hopping Tool in Agrochemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c00997
Abstract: Replacing one ring in a molecule by a different carba- or heterocycle is an important scaffold hopping manipulation, because biologically active compounds and their analogues, which underwent such a transformation, are often similar in size,… read more here.
Keywords: ring exchange; exchange useful; useful scaffold; isosteric ring ... See more keywords