Initiator Types and the Causal Question of the Prevalent New User Design: A Simulation Study.
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DOI: 10.1093/aje/kwaa283
Abstract: New user designs restricting to treatment initiators have become the preferred design for studying drug comparative safety and effectiveness using non-experimental data. This design reduces confounding by indication and healthy adherer bias at the cost… read more here.
Keywords: treatment; study; user design; prevalent new ... See more keywords
Invited Commentary: The Prevalent New User Design in Pharmacoepidemiology: Challenges and Opportunities.
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DOI: 10.1093/aje/kwaa284
Abstract: The prevalent new user design includes a broader study population than the traditional new user approach that is frequently used in pharmacoepidemiologic research. In an article appearing in this issue (Am J Epidemiol. XXXX;XXX(XX):XXXX-XXXX), Webster-Clark… read more here.
Keywords: user design; invited commentary; prevalent new; new user ... See more keywords
The prevalent new-user design for studies with no active comparator: The example of statins and cancer.
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DOI: 10.1097/ede.0000000000001628
Abstract: BACKGROUND Observational studies evaluating the effect of a drug versus "non-use" are challenging, mainly when defining cohort entry for non-users. The approach using successive monthly cohorts to emulate the randomized trial can be perceived as… read more here.
Keywords: design; prevalent new; user design; new user ... See more keywords