Uses of Anthranilic Acid for the Synthesis of Dihydroquinazolin Derivatives with Antitumor, Antiproliferative and Pim-1 kinase Activities.
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DOI: 10.17344/acsi.2017.4146
Abstract: The reaction of anthranilic acid with ethoxycarbonylisothiocyanate gave the ethyl 4-oxo-2-thioxo-1,2-dihydroquinazoline-3(4H)-carboxylate (4). The reaction of compound 4 with hydrazine hydrate and ∆-halocarbonyl derivatives was found to give either hydrazono or S-alkylated products. Heterocyclization reactions of… read more here.
Keywords: pim kinase; dihydroquinazolin derivatives; synthesis dihydroquinazolin; anthranilic acid ... See more keywords