Accurate Prediction of Enzyme Thermostabilization with Rosetta Using AlphaFold Ensembles
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01083
Abstract: Thermostability enhancement is a fundamental aspect of protein engineering as a biocatalyst’s half-life is key for its industrial and biotechnological application, particularly at high temperatures and under harsh conditions. Thermostability changes upon mutation originate from… read more here.
Keywords: accurate prediction; rosetta; using alphafold; prediction ... See more keywords
Solubility-Aware Protein Binding Peptide Design Using AlphaFold
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071626
Abstract: New protein–protein interactions (PPIs) are being identified, but PPIs have different physicochemical properties compared with conventional targets, making it difficult to use small molecules. Peptides offer a new modality to target PPIs, but designing appropriate… read more here.
Keywords: solubility aware; solubility; using alphafold; design ... See more keywords