Neuroprotection and vasculoprotection using genetically targeted protease-ligands
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.03.010
Abstract: Thrombin and activated protein C (APC) are known coagulation factors that exhibit profound effects in brain by acting on the protease activated receptor (PAR). The wild type (WT) proteases appear to impact cell survival powerfully,… read more here.
Keywords: vascular disruption; protease; vasculoprotection using; apc ... See more keywords
Enzymatic Recording of Local Hydrogen Peroxide Generation Using Genetically Encodable Enzyme.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01966
Abstract: Reactive oxygen species (ROS) are endogenously generated in live cells and essential for cell signaling. However, excess ROS generation can cause oxidative damage to biomolecules, which are implicated in various human diseases, including aging. Here,… read more here.
Keywords: hydrogen peroxide; using genetically; generation; h2o2 ... See more keywords
Fluorogenic protein labeling using a genetically encoded unstrained alkene† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc03635j Click here for additional data file.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c6sc03635j
Abstract: A new fluorogenic bioorthogonal reaction between styrene (an unstrained alkene) and a tetrazine was developed. read more here.
Keywords: protein labeling; labeling using; fluorogenic protein; unstrained alkene ... See more keywords
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1721899115
Abstract: Significance Next-generation sequencing (NGS) has allowed the comprehensive study of the genome and transcriptome. However, a similarly broad, highly multiplexed, and inexpensive method for proteomics using NGS remains elusive. Here, we describe a phage display-based… read more here.
Keywords: using genetically; surface; highly multiplexed; cell surface ... See more keywords
Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Microbiology"
DOI: 10.1111/cmi.13282
Abstract: Candida albicans is a major fungal pathogen that can utilise hemin and haemoglobin as iron sources in the iron‐scarce host environment. While C. albicans is a heme prototroph, we show here that it can also… read more here.
Keywords: heme; genetically encoded; mechanisms heme; candida albicans ... See more keywords
Photoacoustic imaging using genetically encoded reporters: a review
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomedical Optics"
DOI: 10.1117/1.jbo.22.7.070901
Abstract: Abstract. Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin. The use of reporter genes expressing absorbing proteins opens the possibility of visualizing… read more here.
Keywords: encoded reporters; photoacoustic imaging; genetically encoded; imaging using ... See more keywords
Protective Cancer Vaccine Using Genetically Modified Hematopoietic Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "Vaccines"
DOI: 10.3390/vaccines6030040
Abstract: Hematopoietic stem cells (HSCs) yield both the myeloid and lymphoid lineages of blood cells and can be reprogrammed into tumor antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) to prevent tumor growth. However, the optimal approach… read more here.
Keywords: protective cancer; genetically modified; hematopoietic stem; using genetically ... See more keywords