Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13480-z
Abstract: The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of… read more here.
Keywords: malaria susceptibility; genome wide; using genome; susceptibility using ... See more keywords
Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42808
Abstract: Advances in genome sequencing technologies and genome-wide association studies (GWAS) have provided unprecedented insights into the molecular basis of microbial phenotypes and enabled the identification of the underlying genetic variants in real populations. However, utilization… read more here.
Keywords: deciphering distance; sequencing data; using genome; resistance ... See more keywords
The identification of mediating effects using genome-based restricted maximum likelihood estimation
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010638
Abstract: Mediation analysis is commonly used to identify mechanisms and intermediate factors between causes and outcomes. Studies drawing on polygenic scores (PGSs) can readily employ traditional regression-based procedures to assess whether trait M mediates the relationship… read more here.
Keywords: based restricted; health; effect; genome based ... See more keywords
Elucidating biogeographical patterns in Australian native canids using genome wide SNPs
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DOI: 10.1371/journal.pone.0198754
Abstract: Dingoes play a strong role in Australia’s ecological framework as the apex predator but are under threat from hybridization and agricultural control programs. Government legislation lists the conservation of the dingo as an important aim,… read more here.
Keywords: genome wide; patterns australian; conservation; using genome ... See more keywords