Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00130
Abstract: Reactive oxygen species (ROS) are essential cellular metabolites widely implicated in many diseases including cancer, inflammation, and cardiovascular and neurodegenerative disorders. Yet, ROS signaling remains poorly understood, and their measurements are a challenge due to… read more here.
Keywords: detection; 13c thiourea; time; h2o2 ... See more keywords
Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12086-z
Abstract: The mammalian brain relies primarily on glucose as a fuel to meet its high metabolic demand. Among the various techniques used to study cerebral metabolism, 13C magnetic resonance spectroscopy (MRS) allows following the fate of… read more here.
Keywords: metabolism; cerebral metabolism; magnetic resonance; hyperpolarized 13c ... See more keywords
Metabolic imaging using hyperpolarized 13C‐pyruvate to assess sensitivity to the B‐Raf inhibitor vemurafenib in melanoma cells and xenografts
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14890
Abstract: Nearly all melanoma patients with a BRAF‐activating mutation will develop resistance after an initial clinical benefit from BRAF inhibition (BRAFi). The aim of this work is to evaluate whether metabolic imaging using hyperpolarized (HP) 13C… read more here.
Keywords: melanoma; pyruvate; conversion; imaging using ... See more keywords
Preclinical MRI Using Hyperpolarized 129Xe
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238338
Abstract: Although critical for development of novel therapies, understanding altered lung function in disease models is challenging because the transport and diffusion of gases over short distances, on which proper function relies, is not readily visualized.… read more here.
Keywords: gas; spectroscopy; using hyperpolarized; mri using ... See more keywords