Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study.
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DOI: 10.1111/cts.13069
Abstract: Sorafenib improves outcomes in adult hepatocellular carcinoma; however, hand foot skin reaction (HFSR) is a dose limiting toxicity of sorafenib that limits its use. HFSR has been associated with sorafenib systemic exposure. The objective of… read more here.
Keywords: hepatocellular carcinoma; using pharmacokinetically; study; sorafenib ... See more keywords