Exploration of Reduced Doses and Short-Cycle Therapy for Darunavir/Cobicistat in Patients with HIV Using Population Pharmacokinetic Modeling and Simulations
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DOI: 10.1007/s40262-020-00920-z
Abstract: Protease inhibitors such as darunavir are an important therapeutic option in the anti-human immunodeficiency virus arsenal. Current dosage guidelines recommend using cobicistat- or ritonavir-boosted darunavir 800 mg every 24 h (q24h) in protease inhibitor-naïve patients,… read more here.
Keywords: pharmacokinetic modeling; darunavir; population pharmacokinetic; using population ... See more keywords
Health utilities in people with chronic pain using a population-level survey and linked health care administrative data
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DOI: 10.1097/j.pain.0000000000000776
Abstract: Abstract Health utilities are a preference-based measure of health-related quality of life that facilitates comparison of disease burden across conditions. We estimated utilities using a population-based, matched sample of adolescents and adults with and without… read more here.
Keywords: survey; health utilities; using population; chronic pain ... See more keywords
Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling
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DOI: 10.1128/aac.01899-21
Abstract: We determined optimal vancomycin starting dose regimens in infants ≤180 days of age to achieve the highest probability of target attainment with an area under the concentration-time curve for 24 h (AUC24) of ≥400 using population… read more here.
Keywords: clearance; age; population pharmacokinetic; pharmacokinetic modeling ... See more keywords
Using Population Mobility Patterns to Adapt COVID-19 Response Strategies in 3 East Africa Countries
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DOI: 10.3201/eid2813.220848
Abstract: The COVID-19 pandemic spread between neighboring countries through land, water, and air travel. Since May 2020, ministries of health for the Democratic Republic of the Congo, Tanzania, and Uganda have sought to clarify population movement… read more here.
Keywords: response strategies; mobility patterns; using population; response ... See more keywords
Developing and Validating Risk Scores for Predicting Major Cardiovascular Events Using Population Surveys Linked with Electronic Health Insurance Records
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DOI: 10.3390/ijerph19031319
Abstract: A risk prediction model for major cardiovascular events was developed using population survey data linked to National Health Insurance (NHI) claim data and the death registry. Another set of population survey data were used to… read more here.
Keywords: health; major cardiovascular; health insurance; using population ... See more keywords