Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics
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DOI: 10.1002/med.21889
Abstract: Many drugs can bind directly to proteins or be bioactivated by metabolizing enzymes to form reactive metabolites (RMs) that rapidly bind to proteins to form drug−protein conjugates or metabolite−protein conjugates (DMPCs). The close relationship between… read more here.
Keywords: drug discovery; shotgun proteomics; using shotgun; metabolite protein ... See more keywords
Using Shotgun Sequencing to Describe the Changes Induced by In-Feed Zinc Oxide and Apramycin in the Microbiomes of Pigs One Week Postweaning
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DOI: 10.1128/spectrum.01597-22
Abstract: Weaning is a critical period for piglets, during which potentially harmful bacteria such as Escherichia coli can increase in abundance in the intestine, creating digestive problems and diarrhea. In-feed antibiotics, the most frequent administration route… read more here.
Keywords: shotgun sequencing; feed; abundance; using shotgun ... See more keywords
Proteomic profile of the lens in a streptozotocin-induced diabetic rat model using shotgun proteomics.
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DOI: 10.3892/br.2017.988
Abstract: Streptozotocin (STZ)-induced diabetic rats (STZ rats) were used to investigate diabetic cataracts. In the current study, a shotgun liquid chromatography (LC)/mass spectrometry (MS)-based global proteomic analysis method was used to examine the mechanism of lens… read more here.
Keywords: compared normal; induced diabetic; normal rats; using shotgun ... See more keywords