Direct C(sp3)-H functionalization of 2-methylazaarenes using 4-substituted-TEMPO
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DOI: 10.1016/j.tetlet.2018.10.014
Abstract: Abstract An efficient and direct C(sp3)-H functionalization of 2-methyl azaarenes with persistent nitroxide radical 4-substituted-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) under neutral conditions has been developed. A broad of 2-methylazaarenes could be reacted with 4-substituted TEMPOs to afford corresponding… read more here.
Keywords: methylazaarenes using; sp3 functionalization; direct sp3; using substituted ... See more keywords
Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3-d]pyrimidines as Targeting Ligands.
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DOI: 10.1021/acs.jmedchem.4c02995
Abstract: Tumor-associated macrophages (TAMs) are highly plastic tumor-infiltrating immune cells. Their reprogramming has emerged as a pivotal strategy in antitumor immunotherapy. The TLR7/8 agonist, IMDQ, has significant potential for reprogramming macrophages but lacks target specificity. To… read more here.
Keywords: using substituted; associated macrophages; chimeric molecules; tumor associated ... See more keywords