Efficient synthesis of (S)-2-chloro-1-(2, 4-dichlorophenyl) ethanol using a tetrad mutant alcohol dehydrogenase from Lactobacillus kefir
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DOI: 10.1016/j.procbio.2019.07.008
Abstract: Abstract As the key chiral intermediate of luliconazole, (S)-2-chloro-1-(2, 4-dichlorophenyl) ethanol ((S)-CPEO) was prepared from 2-chloro-1-(2, 4-dichlorophenyl) ethanone (CPE) using a tetrad mutant alcohol dehydrogenase (A94T/F147L/L199H/A202L) from Lactobacillus kefir (LK-TADH) coupled with glucose dehydrogenase (GDH).… read more here.
Keywords: chloro dichlorophenyl; dichlorophenyl; tetrad mutant; dehydrogenase ... See more keywords