(+)-Usnic acid modulates the Nrf2-ARE pathway in FaDu hypopharyngeal carcinoma cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-021-04092-7
Abstract: Naturally occurring phytochemicals of different origin and structure, arctigenin, bergenin, usnic acid and xanthohumol, were shown to affect Nrf2 pathway in the context of various diseases, but their effect on this pathway in cancer cells… read more here.
Keywords: nrf2 pathway; usnic acid; fadu hypopharyngeal; carcinoma cells ... See more keywords
Anti-inflammatory effects of usnic acid in an MPTP-induced mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146642
Abstract: Neuroinflammation is often associated with astrocyte and microglial activations particularly in Parkinson's disease (PD) and other brain damage such as Alzheimer's disease. Therefore, the modulation of glial activation offers a possible target for treating PD-associated… read more here.
Keywords: usnic acid; effects usnic; parkinson disease; acid ... See more keywords
Overcoming deterrent metabolites by gaining essential nutrients: A lichen/snail case study.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.04.019
Abstract: Specialised metabolites in lichens are generally considered repellent compounds by consumers. Nevertheless, if the only food available is lichens rich in specialised metabolites, lichenophages must implement strategies to overcome the toxicity of these metabolites. Thus,… read more here.
Keywords: case study; deterrent metabolites; snail; usnic acid ... See more keywords
Quantitative variations of usnic acid and selected elements in terricolous lichen Cladonia mitis Sandst., with respect to different environmental factors - A chemometric approach.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.112948
Abstract: In the present study, quantitative analysis of usnic acid and the selected elements (Ag, Ca, Cd, Cr, Cu, Mg, Mn, Ni, Pb, Zn) in samples of Cladonia mitis thalli collected along a North-Central Europe transect,… read more here.
Keywords: usnic acid; selected elements; cladonia mitis; acid ... See more keywords
Ochuscins A‒G, highly oxygenated usnic acid derivatives from the deep-sea-derived fungus Ochroconis sp. FS449
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131066
Abstract: Abstract Ochuscins A‒G (1–7), seven highly oxygenated usnic acid derivatives were isolated from the deep-sea-derived fungus Ochroconis sp. FS449. Their structures were elucidated based on the 1D, 2D NMR, HRESIMS and single crystal X-ray diffraction,… read more here.
Keywords: deep sea; sea derived; usnic acid; highly oxygenated ... See more keywords
Synthesis and biological evaluation of (+)-usnic acid derivatives as potential anti-Toxoplasma gondii agents.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b02173
Abstract: Six series of (+)-usnic acid derivatives were synthesized. The IC50 values of these compounds were determined in T. gondii-infected HeLa cells (μM) and in HeLa cells (μM), and their selectivity indexes (SI) were calculated. In… read more here.
Keywords: usnic acid; compound; gondii agents; acid derivatives ... See more keywords
Usnic acid deteriorates acidogenicity, acidurance and glucose metabolism of Streptococcus mutans through downregulation of two-component signal transduction systems
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80338-6
Abstract: The principal etiological agent of human dental caries, Streptococcus mutans is a multi-virulent pathogen that can transform commensal oral microbial community to plaque biofilms. Major virulence factors that are associated with the cariogenicity of S.… read more here.
Keywords: acid deteriorates; usnic acid; concentration; deteriorates acidogenicity ... See more keywords
Usnic Acid Treatment Changes the Composition of Mycobacterium tuberculosis Cell Envelope and Alters Bacterial Redox Status
Sign Up to like & getrecommendations! Published in 2021 at "mSystems"
DOI: 10.1128/msystems.00097-21
Abstract: The evaluation of mechanisms of mycobacterial response to natural products has been barely studied. However, it might be helpful to reveal bacterial adaptation strategies, which are eventually crucial for the discovery of new drug targets… read more here.
Keywords: acid treatment; tuberculosis; usnic acid; cell envelope ... See more keywords
Liposomal Formulation Improves the Bioactivity of Usnic Acid in RAW 264.7 Macrophage Cells Reducing its Toxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug delivery"
DOI: 10.2174/1567201820666230111112415
Abstract: BACKGROUND Reactive oxygen species (ROS) production and oxidative stress may be responsible for the onset of several chronic diseases. Usnic acid (UA) is a natural secondary metabolite of lichens with several healthful bioactivities, including antioxidant… read more here.
Keywords: liposomal formulation; solubility; toxicity; usnic acid ... See more keywords
Overexpression of the adeB Efflux Pump Gene in Tigecycline-Resistant Acinetobacter baumannii Clinical Isolates and Its Inhibition by (+)Usnic Acid as an Adjuvant
Sign Up to like & getrecommendations! Published in 2021 at "Antibiotics"
DOI: 10.3390/antibiotics10091037
Abstract: Acinetobacter species are among the most life-threatening Gram-negative bacilli, causing hospital-acquired infections, and they are associated with high morbidity and mortality. They show multidrug resistance that acts via various mechanisms. In Acinetobacter baumannii, efflux pump-mediated… read more here.
Keywords: tigecycline; efflux pump; pump; usnic acid ... See more keywords
Effectiveness of a Self-Decontaminating Coating Containing Usnic Acid in Reducing Environmental Microbial Load in Tertiary-Care Hospitals
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph20085434
Abstract: Surfaces have been implicated in the transmission of pathogens in hospitals. This study aimed to assess the effectiveness of an usnic-acid-containing self-decontaminating coating in reducing microbial surface contamination in tertiary-care hospitals. Samples were collected from… read more here.
Keywords: usnic acid; acid; phase; load ... See more keywords