Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IκBα.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.004
Abstract: Post translational modifications, ubiquitination and its reversal by deubiquitination play an important role in regulating innate immune system. USP12 is a poorly studied deubiquitinase reported to regulate T-cell receptor signalling however the functional role of… read more here.
Keywords: lps induced; usp12 promotes; macrophage; deubiquitinase usp12 ... See more keywords
USP12 promotes CD4+ T cell responses through deubiquitinating and stabilizing BCL10
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-021-00787-y
Abstract: Deubiquitinases (DUBs) regulate diverse biological processes and represent a novel class of drug targets. However, the biological function of only a small fraction of DUBs, especially in adaptive immune response regulation, is well-defined. In this… read more here.
Keywords: usp12 promotes; bcl10; promotes cd4; cd4 cell ... See more keywords