LAUSR

USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1.

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0 Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.110174

Abstract: Lipogenesis plays a critical role in colorectal carcinogenesis, but precisely how remains unclear. Here, we show that ERK2 phosphorylates ME1 at T103, thereby inhibiting its polyubiquitination and proteasomal degradation and enhancing its interaction with USP19.… read more here.

Keywords: carcinogenesis; usp19 exacerbates; colorectal carcinogenesis; lipogenesis colorectal ... See more keywords