Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800612
Abstract: Deubiquitinases are important components of the protein regulatory network and, hence, constitute a tempting drug target. We report herein structure–activity relationship studies to develop halogen‐substituted isoquionoline‐1,3‐dione‐based inhibitors of the deubiquitinase USP2. In contrast to our… read more here.
Keywords: switches selectivity; inhibition; halogen substituents; halogen ... See more keywords