USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
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DOI: 10.1182/blood-2017-10-811760
Abstract: Ras mutations are commonly observed in juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML). JMML and CMML transform into acute myeloid leukemia (AML) in about 10% and 50% of patients, respectively. However, how additional… read more here.
Keywords: usp22 deficiency; myeloid leukemia; krasg12d; mice ... See more keywords