Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
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DOI: 10.2139/ssrn.4367388
Abstract: Ubiquitin-specific proteases (USPs) 28 is overexpressed in multiple types of cancers. The development of potent USP28 inhibitors is still in primitive stage. We previously reported our discovery of Vismodegib as a USP28 inhibitor by screening… read more here.
Keywords: vismodegib; usp28 inhibitors; structure based; potent usp28 ... See more keywords