Discovery of Orally Bioavailable N-Benzylpiperidinol Derivatives as Potent and Selective USP7 Inhibitors with In Vivo Antitumor Immunity Activity against Colon Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01444
Abstract: USP7 emerges as a potential therapeutic target for cancers, as it plays an important role in the development of tumorigenesis by stabilizing multiple cancer-relevant proteins. Nevertheless, the discovery of drug-like USP7 inhibitors remains challenging. Herein,… read more here.
Keywords: derivatives potent; selective usp7; usp7 inhibitors; benzylpiperidinol derivatives ... See more keywords
A patent review of ubiquitin-specific protease 7 (USP7) inhibitors (2014-present)
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DOI: 10.1080/13543776.2022.2058873
Abstract: ABSTRACT Introduction Ubiquitin-specific protease 7 (USP7) plays a critical role in multiple signaling pathways, and many recent studies have proved its association with many diseases. The USP7-murine double minute 2-p53 pathway and the relationship between… read more here.
Keywords: specific protease; ubiquitin specific; protease usp7; usp7 inhibitors ... See more keywords
Abstract 6157: USP7 is a promising thersapeutic target for neuroblastoma
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DOI: 10.1158/1538-7445.am2023-6157
Abstract: Background: The ubiquitin-proteasome system (UPS) plays an essential role in post-translational modification of proteins to maintain proteostasis. Ubiquitination of target protein is coordinated by different enzymes, which add and link ubiquitin to each other in… read more here.
Keywords: cell; inhibition; usp7 inhibitors; cancer ... See more keywords