SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors
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DOI: 10.1530/ec-20-0035
Abstract: Objective Somatostatin receptor type 5 (SST5) is inconsistently expressed by corticotroph tumors, with higher expression found in corticotropinomas having ubiquitin-specific protease 8 (USP8) mutations. Aims were to study the correlation between characteristics of corticotropinomas and… read more here.
Keywords: expression; expression usp8; usp8 mutation; functioning silent ... See more keywords
P720R USP8 Mutation Is Associated with a Better Responsiveness to Pasireotide in ACTH-Secreting PitNETs
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DOI: 10.3390/cancers14102455
Abstract: Simple Summary Somatic mutations in USP8 gene have been identified in 11–60% of patients with ACTH-secreting pituitary tumors. This study investigated the impact of USP8 mutations on corticotroph tumor cells responsiveness to the treatment with… read more here.
Keywords: usp8 mutation; acth secreting; p720r usp8; tumor cells ... See more keywords