USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status.
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DOI: 10.1530/eje-19-0194
Abstract: Objective Pituitary corticotroph adenomas commonly cause Cushing's disease (CD) but part of these tumours are hormonally inactive (silent corticotroph adenomas, SCA). USP8 mutations are well known driver mutations in corticotrophinomas. Differences in transcriptomic profiles between… read more here.
Keywords: expression; status; gene expression; corticotroph adenomas ... See more keywords