Intravenous leiomyomatosis is inclined to a solid entity different from uterine leiomyoma based on RNA‐seq analysis with RT‐qPCR validation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3098
Abstract: Intravenous leiomyomatosis (IVL) is currently regarded as a special variant of the common uterine leiomyoma (LM). Though IVL shows a similar histological morphology to LM, IVL is characterized by unique intravenous growth patterns and low‐grade… read more here.
Keywords: inclined solid; leiomyomatosis inclined; intravenous leiomyomatosis; uterine leiomyoma ... See more keywords
CYP24A1 expression analysis in uterine leiomyoma regarding MED12 mutation profile
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05825-7
Abstract: Uterine leiomyoma (ULM) is the most common gynecological tumor. Recent studies have revealed the role of hypovitaminosis D as a major risk factor in the disease development. CYP24A, a mitochondrial enzyme that catalyzes the degradation… read more here.
Keywords: mutation profile; med12 mutation; expression; uterine leiomyoma ... See more keywords
Emerging Roles of Long Non-coding RNAs in Uterine Leiomyoma Pathogenesis: a Review
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Sciences"
DOI: 10.1007/s43032-021-00571-w
Abstract: Uterine leiomyoma (UL), as the most prevalent type of women’s health disorders, is a benign tumor that originates from the smooth muscle cell layer of the uterus. A great number of associated complications are observed… read more here.
Keywords: coding rnas; emerging roles; long non; pathogenesis ... See more keywords
Small bowel volvulus due to torsion of pedunculated uterine leiomyoma: CT findings.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical imaging"
DOI: 10.1016/j.clinimag.2016.09.009
Abstract: Torsion of a uterine leiomyoma is a rare complication that can be life threatening because of ischemia or necrosis. This condition may also lead to gastrointestinal complications such as obstruction or, more rarely, small bowel… read more here.
Keywords: small bowel; bowel volvulus; torsion; uterine leiomyoma ... See more keywords
Abdominal pregnancy implanted on surface of pedunculated subserosal uterine leiomyoma: A case report
Sign Up to like & getrecommendations! Published in 2019 at "Case Reports in Women's Health"
DOI: 10.1016/j.crwh.2019.e00149
Abstract: Highlights • No case of abdominal pregnancy implanted on the surface of a subserosal uterine leiomyoma has previously been reported.• We herein report the case of abdominal pregnancy implanted on the surface of a pedunculated… read more here.
Keywords: subserosal uterine; implanted surface; case; uterine leiomyoma ... See more keywords
Simvastatin, at clinically relevant concentrations, affects human uterine leiomyoma growth and extracellular matrix production.
Sign Up to like & getrecommendations! Published in 2018 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2018.07.024
Abstract: OBJECTIVE To observe the antifibroid effects of therapeutic concentrations of simvastatin, which interferes with cholesterol biosynthesis, a known precursor of five major classes of steroid hormones, including progesterone and estrogen, which play a major role… read more here.
Keywords: leiomyoma cells; production; simvastatin; extracellular matrix ... See more keywords
Ulipristal acetate decreases active TGF-β3 and its canonical signaling in uterine leiomyoma via two novel mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2018.12.026
Abstract: OBJECTIVE To characterize the effect of ulipristal acetate (UPA) treatment on transforming growth factor (TGF) canonical and noncanonical signaling pathways in uterine leiomyoma tissue and cells. UPA decreased extracellular matrix in surgical specimens; we characterize… read more here.
Keywords: active tgf; canonical signaling; tgf canonical; ulipristal acetate ... See more keywords
Bisphenol A induces human uterine leiomyoma cell proliferation through membrane-associated ERα36 via nongenomic signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.01.001
Abstract: The role of ERα36 in regulating BPA's effects and its potential as a risk factor for human uterine fibroids were evaluated. BPA at low concentrations (10-6 μM - 10 μM) increased proliferation by facilitating progression of hormonally… read more here.
Keywords: nongenomic signaling; signaling pathways; proliferation; membrane associated ... See more keywords
Identification of a novel uterine leiomyoma GWAS locus in a Japanese population
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-58066-8
Abstract: Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total. Here, we performed a two-staged GWAS using 13,746… read more here.
Keywords: japanese population; novel uterine; identification novel; uterine leiomyoma ... See more keywords
P-296 Examining the link between environmental toxin exposure and uterine leiomyoma: a systematic review
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DOI: 10.1093/humrep/deab127.074
Abstract: Is there an association between exposure to certain environmental toxins and the prevalence of uterine leiomyoma in women? Some evidence was obtained to suggest an association between phthalate esters, bisphenol A, heavy metals, persistent organic… read more here.
Keywords: systematic review; exposure; association; uterine leiomyoma ... See more keywords
Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas
Sign Up to like & getrecommendations! Published in 2022 at "Obstetrics and Gynecology"
DOI: 10.1097/aog.0000000000004988
Abstract: Relugolix combination therapy showed sustained improvement of uterine leiomyoma–associated symptoms and patient-reported quality of life through 52 weeks. OBJECTIVE: In the LIBERTY 1 and LIBERTY 2 placebo-controlled trials, once-daily relugolix combination therapy reduced menstrual blood… read more here.
Keywords: uterine leiomyoma; relugolix combination; combination therapy;