Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31754
Abstract: Uterine leiomyomas (ULs) are the most common gynecologic tumors and affect 3 of every 4 women by the age of 50 years. The majority of ULs are classified as conventional tumors, whereas 10% represent various… read more here.
Keywords: uterine leiomyomas; daxx expression; alternative lengthening; lengthening telomeres ... See more keywords
Comparison of Clinical Performance Between Two Generations of Magnetic Resonance-guided Focused Ultrasound Systems in Treatments of Uterine Leiomyomas.
Sign Up to like & getrecommendations! Published in 2020 at "Academic radiology"
DOI: 10.1016/j.acra.2020.06.013
Abstract: OBJECTIVES The aim of this study was to evaluate the impact of technology improvements on the outcomes of magnetic resonance-guided focused ultrasound (MRgFUS) treatments of symptomatic uterine leiomyomas (uterine fibroids). The study compared ablation volumes… read more here.
Keywords: focused ultrasound; uterine leiomyomas; magnetic resonance; resonance guided ... See more keywords
The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2019.05.018
Abstract: BACKGROUND Although uterine leiomyomas and leiomyosarcomas are considered biologically-unrelated tumors, they share morphological and histological characteristics that complicate their differential diagnosis. The long-term therapeutic option for leiomyoma is laparoscopic myomectomy with morcellation, particularly for patients… read more here.
Keywords: leiomyosarcomas using; leiomyomas; uterine leiomyomas; leiomyomas leiomyosarcomas ... See more keywords
Uterine Artery Embolization and Surgical Methods for the Treatment of Symptomatic Uterine Leiomyomas: A Systemic Review and Meta-analysis Followed by Indirect Treatment Comparison.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.05.346
Abstract: PURPOSE There is significant discussion and uncertainty about the optimal management of symptomatic uterine leiomyomas (SULs). Nonsurgical procedures such as uterine artery embolization (UAE) have been developed. The goal of this study was to conduct… read more here.
Keywords: uterine leiomyomas; risk; treatment; uterine artery ... See more keywords
Global metabolomic profiling of uterine leiomyomas
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.361
Abstract: Background:Uterine leiomyomas can be classified into molecularly distinct subtypes according to their genetic triggers: MED12 mutations, HMGA2 upregulation, or inactivation of FH. The aim of this study was to identify metabolites and metabolic pathways that… read more here.
Keywords: metabolomic profiling; leiomyomas; uterine leiomyomas; profiling uterine ... See more keywords
Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14701-6
Abstract: Uterine leiomyomas (fibroids) are a major source of gynecologic morbidity in reproductive age women and are characterized by the excessive deposition of a disorganized extracellular matrix, resulting in rigid benign tumors. Although down regulation of… read more here.
Keywords: uterine leiomyomas; dysregulation med12; enhancer; transcriptional dysregulation ... See more keywords
Parity associates with chromosomal damage in uterine leiomyomas
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25806-x
Abstract: Mechanical forces in a constrained cellular environment were recently established as a facilitator of chromosomal damage. Whether this could contribute to tumorigenesis is not known. Uterine leiomyomas are common neoplasms that display relatively few chromosomal… read more here.
Keywords: parity; uterine leiomyomas; mechanical forces; damage ... See more keywords
Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88585-x
Abstract: Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from HLRCC (n = 16; FH-mutation confirmed) and… read more here.
Keywords: renal cell; uterine leiomyomas; hereditary leiomyomatosis; leiomyomatosis renal ... See more keywords
Effects of female hormone withdrawal and ulipristal acetate on MED12 mutation positive and negative uterine leiomyomas using a xenograft model
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-23721-5
Abstract: The effects of therapeutic drugs that inhibit female hormone functions on uterine leiomyomas (ULMs) vary among individuals. ULMs are classified into two subtypes with different histological compositions: MED12 mutation-positive and -negative ULMs. The present study… read more here.
Keywords: xenograft; withdrawal; uterine leiomyomas; med12 mutation ... See more keywords
Multiple painful skin papules, uterine leiomyomas and hysterectomy.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and experimental dermatology"
DOI: 10.1093/ced/llac010
Abstract: A 38-year-old woman presented with multiple papules and nodules. Her mother and maternal grandmother had similar lesions, and all three women had undergone hysterectomy at a young age. Histopathogical analysis revealed dense dermal nodules composed… read more here.
Keywords: painful skin; hysterectomy; multiple painful; uterine leiomyomas ... See more keywords
Epigenomic and enhancer dysregulation in uterine leiomyomas.
Sign Up to like & getrecommendations! Published in 2022 at "Human reproduction update"
DOI: 10.1093/humupd/dmac008
Abstract: BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the most common benign gynecological tumors and are found in women of reproductive and postmenopausal age. There is an exceptionally high prevalence of this… read more here.
Keywords: uterine leiomyomas; dna methylation; enhancer;